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Tchem
FABP5
Fatty acid-binding protein 5

Protein Summary
Description
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987). This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid bind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297258
  • ENSP00000297258
  • ENSG00000164687

Symbol
  • EFABP
  • KFABP
  • E-FABP
  • PAFABP
  • PA-FABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
transcription factor perturbation
0.84
PubMedID
0.79
small molecule perturbation
0.77
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.7   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.7   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 75
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
oleic acid
Rendered image for oleic acid
Protein-Protein Interactions (151)
1 – 10 of 151
S100A7
Tbio
Novelty:  0.00434262
Score:  0.978
Data Source:  STRINGDB
PPARD
Tchem
Family:  NR
Novelty:  0.00271873
Score:  0.948
Data Source:  Reactome,STRINGDB
LIPE
Tchem
Family:  Enzyme
Novelty:  0.00169872
Score:  0.943
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.929
Data Source:  Reactome,STRINGDB
ACLY
Tclin
Family:  Enzyme
Novelty:  0.00114812
Score:  0.923
Data Source:  STRINGDB
SERPINB3
Tbio
Novelty:  0.00325244
Score:  0.921
Data Source:  STRINGDB
TTR
Tclin
Novelty:  0.0001199
Score:  0.917
Data Source:  STRINGDB
RETN
Tbio
Novelty:  0.00062517
Score:  0.917
Data Source:  STRINGDB
ANXA2
Tbio
Novelty:  0.00103362
Score:  0.917
Data Source:  STRINGDB
FUCA1
Tchem
Family:  Enzyme
Novelty:  0.00961721
Score:  0.912
Data Source:  STRINGDB
Pathways (16)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Neutrophil degranulation
Gene Ontology Terms (30)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 5
VGNC:6678
746909
Mouse
MGI:101790
16592
Rat
RGD:70997
140868
Horse
fatty acid binding protein 5
100057538
Cow
fatty acid binding protein 5 [Source:HGNC Symbol;Acc:HGNC:3560]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 5
Mouse
Rat
Horse
fatty acid binding protein 5
Cow
fatty acid binding protein 5 [Source:HGNC Symbol;Acc:HGNC:3560]
Publication Statistics
PubMed Score 220.70
PubMed score by year
PubTator Score 110.70
PubTator score by year