Tchem AMPD2 AMP deaminase 2

Protein Summary

Description

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q01433
• B4DK50
• B4DZI5
• E9PNG0
• Q14856
• Q14857
• Q16686
• Q16687
• Q16688
• Q16729
• Q5T693
• Q5T695
• Q96IA1
• Q9UDX8
• Q9UDX9
• Q9UMU4

Gene Name

• AMPD2

Ensembl ID

• ENST00000256578
• ENSP00000256578
• ENSG00000116337
• ENST00000342115
• ENSP00000345498
• ENST00000358729
• ENSP00000351573
• ENST00000393688
• ENSP00000377292
• ENST00000528454
• ENSP00000437164
• ENST00000528667
• ENSP00000436541

Symbol

• PCH9
• SPG63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
transcription factor	0.8
transcription factor perturbation	0.74
kinase perturbation	0.66
virus perturbation	0.64

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.26   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.26   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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GENEVA

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Active Ligands (7)

Explore Active Ligands

1 – 7 of 7

CHEMBL35929

AMPD2Tchem Enzyme

pKi : 6.39

CHEMBL36045

AMPD2Tchem Enzyme

pKi : 6.52

CHEMBL290887

AMPD2Tchem Enzyme

pKi : 6.1

CHEMBL38113

AMPD2Tchem Enzyme

pKi : 6.1

CHEMBL417506

AMPD2Tchem Enzyme

pKi : 6.07

CHEMBL284799

AMPD2Tchem Enzyme

pKi : 6.04

CHEMBL37713

AMPD2Tchem Enzyme

pKi : 6.01

Protein-Protein Interactions (108)

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1 – 10 of 108

• See Interactions on String-DB

PAGE1

Tbio

Novelty:  0.02731969

p_int:  0.999999939

p_ni:  6.1e-8

Data Source:  BioPlex

AMPD3

Tchem

Family:  Enzyme

Novelty:  0.01230806

p_int:  0.999999585

p_ni:  4.15e-7

Score:  0.809

Data Source:  BioPlex,STRINGDB

EPS8

Tbio

Family:  Enzyme

Novelty:  0.01023541

p_int:  0.999994244

p_ni:  0.00000571

p_wrong:  4.6e-8

Score:  0.193

Data Source:  BioPlex,STRINGDB

CD44

Tbio

Novelty:  0.00011321

p_int:  0.999955489

p_ni:  0.000044508

p_wrong:  3e-9

Data Source:  BioPlex

GPBP1L1

Tdark

Novelty:  0.69320833

p_int:  0.999926344

p_ni:  0.000073655

p_wrong:  1e-9

Data Source:  BioPlex

EIF1AD

Tdark

Novelty:  0.23915521

p_int:  0.999813615

p_ni:  0.000186385

Data Source:  BioPlex

DCAF8

Tbio

Novelty:  0.12456534

p_int:  0.99976518

p_ni:  0.000234811

p_wrong:  1e-8

Data Source:  BioPlex

IL7R

Tbio

Novelty:  0.00107223

p_int:  0.999681947

p_ni:  0.000318053

Data Source:  BioPlex

SDC2

Tbio

Novelty:  0.00597758

p_int:  0.999373513

p_ni:  0.000626486

p_wrong:  1e-9

Data Source:  BioPlex

LZTS2

Tbio

Novelty:  0.09515452

p_int:  0.998601377

p_ni:  0.001398617

p_wrong:  6e-9

Data Source:  BioPlex

Pathways (8)

Reactome (4)

KEGG (2)

PathwayCommons (1)

UniProt (1)

Metabolism (R-HSA-1430728)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nucleotides	100 targets	R-HSA-15869
Reactome	Nucleotide salvage	23 targets	R-HSA-8956321
Reactome	Purine salvage	13 targets	R-HSA-74217

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nucleotides	100 targets	R-HSA-15869
Nucleotide salvage	23 targets	R-HSA-8956321
Purine salvage	13 targets	R-HSA-74217

Gene Ontology Terms (8)

Functions (2)

Components (1)

Processes (5)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
AMP deaminase activity	Inferred from Genetic Interaction (IGI)	MGI
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

GWAS Traits (27)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein B measurement	EFO_0004615	2	10	10		98.2
low density lipoprotein cholesterol measurement	EFO_0004611	2	6	7		95.9
body mass index	EFO_0004340	12	3	22		94.4
apolipoprotein A 1 measurement	EFO_0004614	1	2	2		93.6
high density lipoprotein cholesterol measurement	EFO_0004612	1	2	2		92.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein B measurement	EFO_0004615	10		98.2
low density lipoprotein cholesterol measurement	EFO_0004611	7		95.9
body mass index	EFO_0004340	22		94.4
apolipoprotein A 1 measurement	EFO_0004614	2		93.6
high density lipoprotein cholesterol measurement	EFO_0004612	2		92.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Disease mutation
Hereditary spastic paraplegia
Hydrolase
Metal-binding
Methylation
Neurodegeneration
Nucleotide metabolism

GWAS Trait Find Similar Targets

No Header	No Header
anthropometric measurement
apolipoprotein A 1 measurement
apolipoprotein B measurement
appendicular lean mass
aspartate aminotransferase measurement
body fat percentage
body height
body mass index
breast carcinoma
chronotype measurement

MGI Phenotype Find Similar Targets

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growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
mortality/aging
renal/urinary system phenotype

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	adenosine monophosphate deaminase 2	VGNC:84	469403
Macaque	adenosine monophosphate deaminase 2		699561
Mouse	adenosine monophosphate deaminase 2	MGI:88016	109674
Rat	adenosine monophosphate deaminase 2	RGD:2110	362015
Dog	adenosine monophosphate deaminase 2	VGNC:37839	479913

Species	Name	OMA	EggNOG	Inparanoid
Chimp	adenosine monophosphate deaminase 2
Macaque	adenosine monophosphate deaminase 2
Mouse	adenosine monophosphate deaminase 2
Rat	adenosine monophosphate deaminase 2
Dog	adenosine monophosphate deaminase 2

Publication Statistics

PubMed Score 69.26

PubMed score by year

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PubTator Score 25.39

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