Protein Summary
AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- ENST00000256578
- ENSP00000256578
- ENSG00000116337
- ENST00000342115
- ENSP00000345498
- ENST00000358729
- ENSP00000351573
- ENST00000393688
- ENSP00000377292
- ENST00000528454
- ENSP00000437164
- ENST00000528667
- ENSP00000436541
- PCH9
- SPG63
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.83 | ||
transcription factor | 0.8 | ||
transcription factor perturbation | 0.74 | ||
kinase perturbation | 0.66 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.26 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 195 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.26 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 195 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (7)
Protein-Protein Interactions (108)
AMPD3
Family: Enzyme
Novelty: 0.01230806
p_int: 0.999999585
p_ni: 4.15e-7
Score: 0.809
Data Source: BioPlex,STRINGDB
EPS8
Family: Enzyme
Novelty: 0.01023541
p_int: 0.999994244
p_ni: 0.00000571
p_wrong: 4.6e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
GPBP1L1
Novelty: 0.69320833
p_int: 0.999926344
p_ni: 0.000073655
p_wrong: 1e-9
Data Source: BioPlex
LZTS2
Novelty: 0.09515452
p_int: 0.998601377
p_ni: 0.001398617
p_wrong: 6e-9
Data Source: BioPlex
Nearest Tclin Targets (17)
Upstream (15)
Downstream (2)
1 – 5 of 15
Pathways (8)
Reactome (4)
KEGG (2)
PathwayCommons (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Purine salvage | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleotide salvage | ||||
Purine salvage | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (1)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Genetic Interaction (IGI) | MGI | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 2 | 10 | 10 | 98.2 | |||||
low density lipoprotein cholesterol measurement | 2 | 6 | 7 | 95.9 | |||||
body mass index | 12 | 3 | 22 | 94.4 | |||||
apolipoprotein A 1 measurement | 1 | 2 | 2 | 93.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 2 | 2 | 92.7 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 10 | 98.2 | |||||
low density lipoprotein cholesterol measurement | 7 | 95.9 | |||||
body mass index | 22 | 94.4 | |||||
apolipoprotein A 1 measurement | 2 | 93.6 | |||||
high density lipoprotein cholesterol measurement | 2 | 92.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | adenosine monophosphate deaminase 2 | VGNC:84 | 469403 | |||||
Macaque | adenosine monophosphate deaminase 2 | 699561 | ||||||
Mouse | MGI:88016 | 109674 | ||||||
Rat | RGD:2110 | 362015 | ||||||
Dog | adenosine monophosphate deaminase 2 | VGNC:37839 | 479913 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | adenosine monophosphate deaminase 2 | |||||
Macaque | adenosine monophosphate deaminase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | adenosine monophosphate deaminase 2 | |||||
Publication Statistics
PubMed Score 69.26
PubMed score by year
PubTator Score 25.39
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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