AMPD2
AMP deaminase 2
Protein Summary
AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- ENST00000256578
- ENSP00000256578
- ENSG00000116337
- ENST00000342115
- ENSP00000345498
- ENST00000358729
- ENSP00000351573
- ENST00000393688
- ENSP00000377292
- ENST00000528454
- ENSP00000437164
- ENST00000528667
- ENSP00000436541
- PCH9
- SPG63
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.83 | ||
transcription factor | 0.8 | ||
transcription factor perturbation | 0.74 | ||
kinase perturbation | 0.66 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.78 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 195 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.78 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 195 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0