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Tchem
AMPD2
AMP deaminase 2

Protein Summary
Description
AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256578
  • ENSP00000256578
  • ENSG00000116337
  • ENST00000342115
  • ENSP00000345498
  • ENST00000358729
  • ENSP00000351573
  • ENST00000393688
  • ENSP00000377292
  • ENST00000528454
  • ENSP00000437164
  • ENST00000528667
  • ENSP00000436541

Symbol
  • PCH9
  • SPG63
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
transcription factor
0.8
transcription factor perturbation
0.74
kinase perturbation
0.66
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.26   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.26   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (108)
PAGE1
Tbio
Novelty:  0.02731969
p_int:  0.999999939
p_ni:  6.1e-8
Data Source:  BioPlex
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
p_int:  0.999999585
p_ni:  4.15e-7
Score:  0.809
Data Source:  BioPlex,STRINGDB
EPS8
Tbio
Family:  Enzyme
Novelty:  0.01023541
p_int:  0.999994244
p_ni:  0.00000571
p_wrong:  4.6e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999955489
p_ni:  0.000044508
p_wrong:  3e-9
Data Source:  BioPlex
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.999926344
p_ni:  0.000073655
p_wrong:  1e-9
Data Source:  BioPlex
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999813615
p_ni:  0.000186385
Data Source:  BioPlex
DCAF8
Tbio
Novelty:  0.12456534
p_int:  0.99976518
p_ni:  0.000234811
p_wrong:  1e-8
Data Source:  BioPlex
IL7R
Tbio
Novelty:  0.00107223
p_int:  0.999681947
p_ni:  0.000318053
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999373513
p_ni:  0.000626486
p_wrong:  1e-9
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.998601377
p_ni:  0.001398617
p_wrong:  6e-9
Data Source:  BioPlex
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 15
PDE1A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE8B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE3A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
10
10
98.2
low density lipoprotein cholesterol measurement
2
6
7
95.9
body mass index
12
3
22
94.4
apolipoprotein A 1 measurement
1
2
2
93.6
high density lipoprotein cholesterol measurement
1
2
2
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
10
98.2
low density lipoprotein cholesterol measurement
7
95.9
body mass index
22
94.4
apolipoprotein A 1 measurement
2
93.6
high density lipoprotein cholesterol measurement
2
92.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine monophosphate deaminase 2
VGNC:84
469403
Macaque
adenosine monophosphate deaminase 2
699561
Mouse
MGI:88016
109674
Rat
RGD:2110
362015
Dog
adenosine monophosphate deaminase 2
VGNC:37839
479913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine monophosphate deaminase 2
Macaque
adenosine monophosphate deaminase 2
Mouse
Rat
Dog
adenosine monophosphate deaminase 2
Publication Statistics
PubMed Score 69.26
PubMed score by year
PubTator Score 25.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title