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Tbio
GALK2
N-acetylgalactosamine kinase

Protein Summary
Description
Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. The encoded protein is a member of the GHMP kinase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327171
  • ENSP00000316632
  • ENSG00000156958
  • ENST00000560031
  • ENSP00000453129

Symbol
  • GK2
  • GK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.91
histone modification site profile
0.86
transcription factor binding site profile
0.84
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
2
2
89.2
2
4
0
1.1
83.1
mean platelet volume
2
2
2
74.7
peak expiratory flow
1
2
2
69.1
forced expiratory volume
1
1
1
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
89.2
0
1.1
83.1
mean platelet volume
2
74.7
peak expiratory flow
2
69.1
forced expiratory volume
1
65.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galactokinase 2
VGNC:3551
744911
Macaque
galactokinase 2
714866
Mouse
MGI:1917226
69976
Rat
RGD:1308691
296117
Dog
galactokinase 2
VGNC:41082
487548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galactokinase 2
Macaque
galactokinase 2
Mouse
Rat
Dog
galactokinase 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01415-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (68)
1 – 10 of 68
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.996096885
p_ni:  0.003903115
Score:  0.284
Data Source:  BioPlex,STRINGDB
CCDC18
Tdark
Novelty:  0.61246881
p_int:  0.963935119
p_ni:  0.006543412
p_wrong:  0.029521469
Score:  0.243
Data Source:  BioPlex,STRINGDB
PABPC3
Tbio
Novelty:  0.13551529
p_int:  0.96068171
p_ni:  0.000002427
p_wrong:  0.039315863
Score:  0.252
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
p_int:  0.943481139
p_ni:  0.056518561
p_wrong:  2.99e-7
Score:  0.231
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.91995722
p_ni:  0.080042609
p_wrong:  1.71e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.877570896
p_ni:  0.122386894
p_wrong:  0.00004221
Data Source:  BioPlex
CD59
Tbio
Novelty:  0.0008352
p_int:  0.837174365
p_ni:  0.001243276
p_wrong:  0.161582359
Score:  0.209
Data Source:  BioPlex,STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.755949684
p_ni:  0.244050316
Score:  0.167
Data Source:  BioPlex,STRINGDB
GALE
Tchem
Family:  Enzyme
Novelty:  0.00256798
Score:  0.985
Data Source:  STRINGDB
GALT
Tbio
Family:  Enzyme
Novelty:  0.0120291
Score:  0.948
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.93

PubMed score by year
PubTator Score  5.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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