Tbio MS4A2 High affinity immunoglobulin epsilon receptor subunit beta

Protein Summary

Description

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q01362
• Q54A81
• FcERI

Gene Name

• MS4A2

Ensembl ID

• ENST00000278888
• ENSP00000278888
• ENSG00000149534

Symbol

• APY
• FCER1B
• IGER
• APY
• IGEL
• IGER
• ATOPY
• FCERI
• IGHER
• MS4A1
• FCER1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.73
molecular function	0.7
disease	0.67
hub protein	0.58
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Receptor / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta

DTO Classes

Protein / Receptor / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.62   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.62   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0