Tclin IL5RA Interleukin-5 receptor subunit alpha

Protein Summary

Description

This is the receptor for interleukin-5. The alpha chain binds to IL5. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q01344
• B3IU77
• B4E2G0
• Q14633
• Q15469
• Q6ISX9
• IL-5 receptor subunit alpha

Gene Name

• IL5RA

Ensembl ID

• ENST00000256452
• ENSP00000256452
• ENSG00000091181
• ENST00000311981
• ENSP00000309196
• ENST00000383846
• ENSP00000373358
• ENST00000430514
• ENSP00000400400
• ENST00000438560
• ENSP00000390753
• ENST00000446632
• ENSP00000412209
• ENST00000456302
• ENSP00000392059

Symbol

• IL5R
• IL5R
• CD125
• CDw125
• HSIL5R3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.78
phenotype	0.7
gene perturbation	0.66
kinase perturbation	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-5 Receptor Subunit Alpha

Protein / Defense/immunity Protein / Interleukin-5 Receptor Subunit Alpha

DTO Classes

Protein / Signaling / Cytokine / Interleukin-5 Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.51   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 365   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.51   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1