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Tclin
IL5RA
Interleukin-5 receptor subunit alpha

Protein Summary
Description
This is the receptor for interleukin-5. The alpha chain binds to IL5. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256452
  • ENSP00000256452
  • ENSG00000091181
  • ENST00000311981
  • ENSP00000309196
  • ENST00000383846
  • ENSP00000373358
  • ENST00000430514
  • ENSP00000400400
  • ENST00000438560
  • ENSP00000390753
  • ENST00000446632
  • ENSP00000412209
  • ENST00000456302
  • ENSP00000392059

Symbol
  • IL5R
  • IL5R
  • CD125
  • CDw125
  • HSIL5R3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
phenotype
0.7
gene perturbation
0.66
kinase perturbation
0.6
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.06   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.06   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
benralizumab
no chemical structure image available
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
5
7
94.2
eosinophil percentage of leukocytes
2
6
6
75.3
basophil percentage of leukocytes
2
3
4
72.3
basophil count
2
2
3
63.4
basophil percentage of granulocytes
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
7
94.2
eosinophil percentage of leukocytes
6
75.3
basophil percentage of leukocytes
4
72.3
basophil count
3
63.4
basophil percentage of granulocytes
1
52.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 5 receptor subunit alpha
VGNC:6296
737582
Macaque
interleukin 5 receptor subunit alpha
704649
Mouse
MGI:96558
16192
Rat
RGD:70938
114103
Dog
interleukin 5 receptor subunit alpha
VGNC:41991
476553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 5 receptor subunit alpha
Macaque
interleukin 5 receptor subunit alpha
Mouse
Rat
Dog
interleukin 5 receptor subunit alpha
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01344-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (390)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-2 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Interleukin receptor SHC signaling
Interleukin-2 family signaling
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (127)
1 – 10 of 127
CNTNAP3
Tdark
Novelty: 0.22791524
p_int: 0.970279507
p_ni: 0.029720493
Data Source: BioPlex
WDTC1
Tbio
Novelty: 0.02300849
p_int: 0.920234838
p_ni: 0.079765162
Data Source: BioPlex
OS9
Tbio
Novelty: 0.01490339
p_int: 0.912438357
p_ni: 0.087561644
Data Source: BioPlex
FKBP14
Tbio
Family: Enzyme
Novelty: 0.02742616
p_int: 0.88526463
p_ni: 0.114708538
p_wrong: 0.000026832
Data Source: BioPlex
XRCC3
Tbio
Novelty: 0.00266163
p_int: 0.855925143
p_ni: 0.144065178
p_wrong: 0.000009678
Data Source: BioPlex
LAMB2
Tbio
Novelty: 0.07966931
p_int: 0.842674864
p_ni: 0.157325136
Data Source: BioPlex
NOMO1
Tbio
Novelty: 0.13625697
p_int: 0.817810238
p_ni: 0.182189762
Data Source: BioPlex
TENM3
Tbio
Novelty: 0.0251948
p_int: 0.775951158
p_ni: 0.163851834
p_wrong: 0.060197008
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.764444298
p_ni: 0.235555702
Data Source: BioPlex
IL5
Tclin
Novelty: 0.0001684
Score: 0.997
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  56.06

PubMed score by year
PubTator Score  101.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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