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Tbio
RELB
Transcription factor RelB

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221452
  • ENSP00000221452
  • ENSG00000104856
  • ENST00000625761
  • ENSP00000485826

Symbol
  • IREL
  • I-REL
  • IMD53
  • REL-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
biological process
0.93
histone modification site profile
0.85
protein domain
0.85
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 422.64   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 422.64   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (229)
NFKB2
Tchem
Family:  TF
Novelty:  0.00366074
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  1
Score:  0.952
Data Source:  BioPlex,STRINGDB
REL
Tbio
Family:  TF
Novelty:  0.00038265
p_int:  1
Score:  0.947
Data Source:  BioPlex,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
p_int:  0.999999545
p_ni:  4.55e-7
Score:  0.974
Data Source:  BioPlex,Reactome,STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
p_int:  0.999998328
p_ni:  1e-8
p_wrong:  0.000001662
Score:  0.995
Data Source:  BioPlex,STRINGDB
NFKBIE
Tbio
Novelty:  0.01726154
p_int:  0.999998004
p_ni:  5.4e-8
p_wrong:  0.000001943
Score:  0.945
Data Source:  BioPlex,STRINGDB
TNIP2
Tbio
Novelty:  0.03640252
p_int:  0.999944693
p_ni:  0.000055306
p_wrong:  2e-9
Score:  0.737
Data Source:  BioPlex,STRINGDB
CTBS
Tbio
Family:  Enzyme
Novelty:  0.00956005
p_int:  0.999679716
p_ni:  0.000060059
p_wrong:  0.000260225
Score:  0.214
Data Source:  BioPlex,STRINGDB
SMARCD2
Tbio
Novelty:  0.04006597
p_int:  0.997638799
p_ni:  0.002361201
Score:  0.782
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.973993165
p_ni:  0.026006835
Score:  0.672
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (34)
C-type lectin receptors (CLRs) (R-HSA-5621481)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Reactome
Dectin-1 mediated noncanonical NF-kB signaling
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Dectin-1 mediated noncanonical NF-kB signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (105)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
28
41
72
12
100
apolipoprotein B measurement
2
33
34
100
total cholesterol measurement
16
33
56
8.6
100
C-reactive protein measurement
11
28
39
21.8
100
17
33
2
3.2
99.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
72
12
100
apolipoprotein B measurement
34
100
total cholesterol measurement
56
8.6
100
C-reactive protein measurement
39
21.8
100
2
3.2
99.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RELB proto-oncogene, NF-kB subunit
VGNC:10425
456119
Macaque
RELB proto-oncogene, NF-kB subunit
714677
Mouse
MGI:103289
19698
Rat
RGD:2321078
100360982
Dog
RELB proto-oncogene, NF-kB subunit
VGNC:45467
484454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RELB proto-oncogene, NF-kB subunit
Macaque
RELB proto-oncogene, NF-kB subunit
Mouse
Rat
Dog
RELB proto-oncogene, NF-kB subunit
Publication Statistics
PubMed Score 422.64
PubMed score by year
PubTator Score 222.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title