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Tbio
FOXK2
Forkhead box protein K2

Protein Summary
Description
Transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335255
  • ENSP00000335677
  • ENSG00000141568
  • ENST00000473637
  • ENSP00000436108

Symbol
  • ILF
  • ILF1
  • ILF
  • ILF1
  • ILF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.95
molecular function
0.88
interacting protein
0.85
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.5   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.5   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
92.3
red blood cell distribution width
4
1
4
83.4
mean corpuscular hemoglobin concentration
1
1
1
74.6
low density lipoprotein cholesterol measurement
1
1
1
68.6
reticulocyte count
4
3
4
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
92.3
red blood cell distribution width
4
83.4
mean corpuscular hemoglobin concentration
1
74.6
low density lipoprotein cholesterol measurement
1
68.6
reticulocyte count
4
65.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box K2
VGNC:12139
454996
Macaque
forkhead box protein K2
719599
Mouse
MGI:1916087
68837
Dog
forkhead box K2 [Source:HGNC Symbol;Acc:HGNC:6036]
Horse
forkhead box K2
VGNC:18107
100056711
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box K2
Macaque
forkhead box protein K2
Mouse
Dog
forkhead box K2 [Source:HGNC Symbol;Acc:HGNC:6036]
Horse
forkhead box K2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01167-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Gene Ontology Terms (14)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (103)
1 – 10 of 103
BAP1
Tbio
Family: Enzyme
Novelty: 0.00501435
p_int: 0.999999624
p_ni: 3.76e-7
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
DVL3
Tbio
Novelty: 0.01606014
p_int: 0.999998862
p_ni: 0.000001138
Score: 0.209
Data Source: BioPlex,STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.999995279
p_ni: 0.000004721
Data Source: BioPlex
ZNF428
Tdark
Novelty: 3.23887218
p_int: 0.999993118
p_ni: 0.000006882
Data Source: BioPlex
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.999990216
p_ni: 0.000009784
Data Source: BioPlex
DVL2
Tbio
Novelty: 0.00833084
p_int: 0.999980547
p_ni: 0.000019453
Score: 0.255
Data Source: BioPlex,STRINGDB
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.999976445
p_ni: 0.000023555
Data Source: BioPlex
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.999973559
p_ni: 0.000026441
Score: 0.181
Data Source: BioPlex,STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.999970087
p_ni: 0.000029913
Score: 0.26
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.9998752
p_ni: 0.0001248
Score: 0.436
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  85.50

PubMed score by year
PubTator Score  25.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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