Protein Summary
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000379153
- ENSP00000368450
- ENSG00000112149
- BL11
- HB15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.98 | ||
gene perturbation | 0.95 | ||
virus perturbation | 0.9 | ||
transcription factor binding site profile | 0.79 | ||
disease | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 747.32 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 863 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 747.32 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 863 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0