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Tbio
SRSF2
Serine/arginine-rich splicing factor 2

Protein Summary
Description
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for bi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359995
  • ENSP00000353089
  • ENSG00000161547
  • ENST00000392485
  • ENSP00000376276
  • ENST00000452355
  • ENSP00000391278
  • ENST00000508921
  • ENSP00000441780
  • ENST00000585202
  • ENSP00000462425

Symbol
  • SFRS2
  • SC35
  • PR264
  • SC-35
  • SFRS2
  • SFRS2A
  • SRp30b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.97
co-expressed gene
0.96
transcription factor perturbation
0.96
kinase perturbation
0.93


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.54   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.54   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 2
VGNC:9656
619467
Macaque
serine and arginine rich splicing factor 2
708105
Mouse
MGI:98284
20382
Rat
RGD:1359422
494445
Dog
serine and arginine rich splicing factor 2
100856058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 2
Macaque
serine and arginine rich splicing factor 2
Mouse
Rat
Dog
serine and arginine rich splicing factor 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01130-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (422)
1 – 10 of 422
KIAA0930
Tbio
Novelty: 0.16492958
p_int: 0.999988585
p_ni: 0.000010999
p_wrong: 4.17e-7
Data Source: BioPlex
RANGRF
Tbio
Family: Enzyme
Novelty: 0.02750539
p_int: 0.999576677
p_ni: 0.000397779
p_wrong: 0.000025543
Data Source: BioPlex
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
p_int: 0.997612811
p_ni: 0.002387186
p_wrong: 3e-9
Data Source: BioPlex
MAPK9
Tchem
Family: Kinase
Novelty: 0.00267199
p_int: 0.996801866
p_ni: 0.003198131
p_wrong: 3e-9
Data Source: BioPlex
KLHL20
Tbio
Novelty: 0.12205871
p_int: 0.9953796
p_ni: 0.004620309
p_wrong: 9.1e-8
Data Source: BioPlex
PARN
Tbio
Family: Enzyme
Novelty: 0.00738516
p_int: 0.994430252
p_ni: 0.005569727
p_wrong: 2.1e-8
Data Source: BioPlex
VPS16
Tbio
Novelty: 0.03575558
p_int: 0.992274047
p_ni: 0.007725953
Data Source: BioPlex
VPS33A
Tbio
Novelty: 0.08316241
p_int: 0.991847892
p_ni: 0.008152108
Data Source: BioPlex
CAMK1
Tchem
Family: Kinase
Novelty: 0.01239891
p_int: 0.98638528
p_ni: 0.013614649
p_wrong: 7.1e-8
Data Source: BioPlex
UQCC1
Tbio
Family: Enzyme
Novelty: 0.03937066
p_int: 0.981950558
p_ni: 0.018049431
p_wrong: 1.1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  462.54

PubMed score by year
PubTator Score  288.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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