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Tclin
SCN7A
Sodium channel protein type 7 subunit alpha

Protein Classes
Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-len ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409855
  • ENSP00000386796
  • ENSG00000136546
  • ENST00000441411
  • ENSP00000403846
  • ENST00000619410
  • ENSP00000478562
  • ENST00000621965
  • ENSP00000481734
  • ENST00000643258
  • ENSP00000496114

Symbol
  • SCN6A
  • NaG
  • SCN6A
  • Nav2.1
  • Nav2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.76
molecular function
0.76
co-expressed gene
0.72
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.82   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.82   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
14.5
1
1
0
1.6
14.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
14.5
0
1.6
14.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sodium voltage-gated channel alpha subunit 7
704414
Mouse
MGI:102965
20272
Rat
RGD:61922
64155
Dog
sodium voltage-gated channel alpha subunit 7
VGNC:45922
488382
Horse
sodium voltage-gated channel alpha subunit 7
VGNC:22741
100062186
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sodium voltage-gated channel alpha subunit 7
Mouse
Rat
Dog
sodium voltage-gated channel alpha subunit 7
Horse
sodium voltage-gated channel alpha subunit 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01118-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Protein-Protein Interactions (46)
1 – 10 of 46
SCN1B
Tbio
Family: IC
Novelty: 0.00910273
Score: 0.967
Data Source: STRINGDB
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
Score: 0.951
Data Source: STRINGDB
SCN4B
Tbio
Family: IC
Novelty: 0.02505113
Score: 0.942
Data Source: STRINGDB
SCN2B
Tbio
Family: IC
Novelty: 0.03773629
Score: 0.938
Data Source: STRINGDB
ANK3
Tbio
Novelty: 0.00429246
Score: 0.926
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.911
Data Source: STRINGDB
ANK1
Tbio
Novelty: 0.00225305
Score: 0.907
Data Source: STRINGDB
SPTBN4
Tbio
Novelty: 0.02182293
Score: 0.904
Data Source: STRINGDB
SPTBN5
Tbio
Novelty: 0.18740061
Score: 0.902
Data Source: STRINGDB
SPTBN2
Tbio
Novelty: 0.01183066
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.82

PubMed score by year
PubTator Score  31.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer