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Tbio
IL9R
Interleukin-9 receptor

Protein Summary
Description
This is a receptor for interleukin-9. The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244174
  • ENSP00000244174
  • ENSG00000124334
  • ENST00000369423
  • ENSP00000358431

Symbol
  • CD129
  • IL-9R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
virus perturbation
0.68
disease perturbation
0.62
tissue sample
0.54
hub protein
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.18   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.18   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
23
eosinophil count
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
23
eosinophil count
1
21.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01113-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (168)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-2 family signaling
Reactome
Interleukin-9 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-2 family signaling
Interleukin-9 signaling
Signaling by Interleukins
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (91)
1 – 10 of 91
EDA
Tbio
Novelty: 0.00352464
p_int: 0.995465291
p_ni: 0.00449095
p_wrong: 0.000043759
Data Source: BioPlex
RETSAT
Tdark
Family: Enzyme
Novelty: 0.10624626
p_int: 0.986537555
p_ni: 0.013462445
Score: 0.179
Data Source: BioPlex,STRINGDB
ZDHHC18
Tdark
Family: Enzyme
Novelty: 0.44878853
p_int: 0.901564632
p_ni: 0.049451719
p_wrong: 0.048983649
Score: 0.179
Data Source: BioPlex,STRINGDB
LSR
Tbio
Novelty: 0.00528058
p_int: 0.894310084
p_ni: 0.105689916
Data Source: BioPlex
SARAF
Tbio
Novelty: 0.0383833
p_int: 0.854827657
p_ni: 0.145074543
p_wrong: 0.0000978
Score: 0.173
Data Source: BioPlex,STRINGDB
NETO2
Tbio
Novelty: 0.0414181
p_int: 0.832440049
p_ni: 0.167559949
p_wrong: 1e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
TMX4
Tdark
Novelty: 0.2628295
p_int: 0.825582044
p_ni: 0.174417956
Score: 0.286
Data Source: BioPlex,STRINGDB
TMEM39A
Tbio
Novelty: 0.11657639
p_int: 0.806601473
p_ni: 0.193398475
p_wrong: 5.1e-8
Score: 0.293
Data Source: BioPlex,STRINGDB
TM2D3
Tbio
Novelty: 0.09408834
p_int: 0.76723669
p_ni: 0.232255899
p_wrong: 0.000507411
Data Source: BioPlex
CCPG1
Tbio
Novelty: 0.07685013
p_int: 0.764830174
p_ni: 0.235169825
Data Source: BioPlex
Publication Statistics
PubMed Score  16.18

PubMed score by year
PubTator Score  42.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer