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Tbio
E2F1
Transcription factor E2F1

Protein Summary
Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally co ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343380
  • ENSP00000345571
  • ENSG00000101412

Symbol
  • RBBP3
  • RBP3
  • E2F-1
  • RBAP1
  • RBBP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
hub protein
0.99
kinase
0.98
virus
0.98
pathway
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.96   (req: < 5)
Gene RIFs: 536   (req: <= 3)
Antibodies: 1343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.96   (req: >= 5)
Gene RIFs: 536   (req: > 3)
Antibodies: 1343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0