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Tbio
SPTBN1
Spectrin beta chain, non-erythrocytic 1

Protein Summary
Description
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333896
  • ENSP00000334156
  • ENSG00000115306
  • ENST00000356805
  • ENSP00000349259

Symbol
  • SPTB2
  • ELF
  • SPTB2
  • HEL102
  • betaSpII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
transcription factor perturbation
1
ligand (protein) perturbation
0.99
microRNA
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.87   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.87   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
11
14
98.5
myeloid white cell count
1
1
1
74.3
neutrophil count
2
1
2
73
bone quantitative ultrasound measurement
3
1
4
71.4
intraocular pressure measurement
2
2
1
6.7
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
14
98.5
myeloid white cell count
1
74.3
neutrophil count
2
73
bone quantitative ultrasound measurement
4
71.4
intraocular pressure measurement
1
6.7
65.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spectrin beta, non-erythrocytic 1
VGNC:486
459234
Macaque
spectrin beta, non-erythrocytic 1
716794
Mouse
MGI:98388
20742
Rat
RGD:727922
305614
Dog
spectrin beta, non-erythrocytic 1
VGNC:46775
403743
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spectrin beta, non-erythrocytic 1
Macaque
spectrin beta, non-erythrocytic 1
Mouse
Rat
Dog
spectrin beta, non-erythrocytic 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01082-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
COPI-mediated anterograde transport
Reactome
Cell-Cell communication
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
COPI-mediated anterograde transport
Cell-Cell communication
Cytokine Signaling in Immune system
Gene Ontology Terms (36)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (208)
1 – 10 of 208
SPTAN1
Tbio
Novelty: 0.00286901
Score: 0.999
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.983
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
ANK3
Tbio
Novelty: 0.00429246
Score: 0.969
Data Source: STRINGDB
ANK1
Tbio
Novelty: 0.00225305
Score: 0.958
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.957
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.951
Data Source: STRINGDB
SPTA1
Tbio
Novelty: 0.00456741
Score: 0.95
Data Source: STRINGDB
ACTR1A
Tbio
Novelty: 0.06306209
Score: 0.947
Data Source: STRINGDB
DYNC1H1
Tbio
Novelty: 0.0098543
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.87

PubMed score by year
PubTator Score  33.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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