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Tbio
U2AF1
Splicing factor U2AF 35 kDa subunit

Protein Summary
Description
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291552
  • ENSP00000291552
  • ENSG00000160201
  • ENST00000380276
  • ENSP00000369629
  • ENST00000398137
  • ENSP00000381205
  • ENST00000459639
  • ENSP00000418705
  • ENST00000464750
  • ENSP00000420672

Symbol
  • U2AF35
  • U2AFBP
  • RN
  • FP793
  • U2AF35
  • U2AFBP
  • RNU2AF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.68   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.68   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
3
4
4
92.6
Age-related nuclear cataract
2
2
1
8.2
71.3
viral load
1
1
1
64.9
blood metabolite measurement
1
1
1
50.6
Alopecia
1
2
2
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
4
92.6
Age-related nuclear cataract
1
8.2
71.3
viral load
1
64.9
blood metabolite measurement
1
50.6
Alopecia
2
34.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
-
737227
Mouse
MGI:98884
108121
Dog
U2 small nuclear RNA auxiliary factor 1
478422
Horse
U2 small nuclear RNA auxiliary factor 1
100057570
Cow
U2 small nuclear RNA auxiliary factor 1
512680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
-
Mouse
Dog
U2 small nuclear RNA auxiliary factor 1
Horse
U2 small nuclear RNA auxiliary factor 1
Cow
U2 small nuclear RNA auxiliary factor 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q01081-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (151)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (201)
1 – 10 of 201
U2AF2
Tbio
Novelty:  0.00590935
p_int:  0.999999834
p_ni:  1.66e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
SCAF11
Tdark
Novelty:  0.00802779
p_int:  0.999999224
p_ni:  7.76e-7
Score:  0.535
Data Source:  BioPlex,STRINGDB
SRPK2
Tchem
Family:  Kinase
Novelty:  0.03217228
p_int:  0.999632666
p_ni:  0.000367334
Score:  0.588
Data Source:  BioPlex,STRINGDB
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
p_int:  0.999138306
p_ni:  0.000861694
Score:  0.677
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.997739329
p_ni:  0.002260671
Score:  0.523
Data Source:  BioPlex,STRINGDB
U2AF1L4
Tbio
Novelty:  0.01735641
p_int:  0.993841336
p_wrong:  0.006158664
Score:  0.817
Data Source:  BioPlex,STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.989623569
p_ni:  0.010376431
Data Source:  BioPlex
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.988354671
p_ni:  0.011645328
p_wrong:  1e-9
Score:  0.363
Data Source:  BioPlex,STRINGDB
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
p_int:  0.855139025
p_ni:  0.14486097
p_wrong:  5e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  188.68

PubMed score by year
PubTator Score  87.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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