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Tclin
PDE1B
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

Protein Summary
Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243052
  • ENSP00000243052
  • ENSG00000123360
  • ENST00000550620
  • ENSP00000448519

Symbol
  • PDE1B1
  • PDES1B
  • PDE1B1
  • PDES1B
  • HEL-S-79p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
protein domain
0.73
gene perturbation
0.69
ligand (protein)
0.68
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.06   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.06   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
dipyridamole
Rendered image for dipyridamole
Active Ligands (41)
1 – 10 of 41
CHEMBL4128481
Rendered image for CHEMBL4128481
SCH51866
Rendered image for SCH51866
(+)-Cyclomorusin
Rendered image for (+)-Cyclomorusin
CHEMBL4067682
Rendered image for CHEMBL4067682
CHEMBL3601563
Rendered image for CHEMBL3601563
CHEMBL1463540
Rendered image for CHEMBL1463540
CHEMBL4644729
Rendered image for CHEMBL4644729
CHEMBL3769414
Rendered image for CHEMBL3769414
US8829000, Referential Example 1
Rendered image for US8829000, Referential Example 1
CHEMBL3356680
Rendered image for CHEMBL3356680
Protein-Protein Interactions (90)
1 – 10 of 90
PDE1C
Tclin
Family:  Enzyme
Novelty:  0.0222243
p_int:  1
Score:  0.968
Data Source:  BioPlex,STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.913
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.907
Data Source:  STRINGDB
PDE1A
Tclin
Family:  Enzyme
Novelty:  0.02694265
Score:  0.905
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.904
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.903
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.901
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.901
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.822
Data Source:  STRINGDB
GNG13
Tbio
Novelty:  0.13011919
Score:  0.808
Data Source:  STRINGDB
Pathways (33)
Ca-dependent events (R-HSA-111996)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca-dependent events
Reactome
CaM pathway
Reactome
Calmodulin induced events
Reactome
Cam-PDE 1 activation
Reactome
DAG and IP3 signaling
Name
Explore in Pharos
Explore in Source
Ca-dependent events
CaM pathway
Calmodulin induced events
Cam-PDE 1 activation
DAG and IP3 signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 1B
VGNC:5524
451962
Macaque
phosphodiesterase 1B
705920
Mouse
MGI:97523
18574
Rat
RGD:3278
29691
Dog
phosphodiesterase 1B
VGNC:44349
100856025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 1B
Macaque
phosphodiesterase 1B
Mouse
Rat
Dog
phosphodiesterase 1B
Publication Statistics
PubMed Score 39.06
PubMed score by year
PubTator Score 18.38
PubTator score by year