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Tdark
PRCD
Progressive rod-cone degeneration protein

Protein Summary
Description
Involved in vision. This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000586148
  • ENSP00000465932
  • ENSG00000214140
  • ENST00000592014
  • ENSP00000467661

Symbol
  • RP36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
cell line
0.66
tissue sample
0.66
microRNA
0.62
phenotype
0.45


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.8   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 1   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.8   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 1   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
photoreceptor disc component
739050
Mouse
MGI:3649529
100038570
Dog
photoreceptor disc component
VGNC:44942
100049006
Cow
photoreceptor disc component
VGNC:33286
100297029
Pig
photoreceptor disc component [Source:HGNC Symbol;Acc:HGNC:32528]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
photoreceptor disc component
Mouse
Dog
photoreceptor disc component
Cow
photoreceptor disc component
Pig
photoreceptor disc component [Source:HGNC Symbol;Acc:HGNC:32528]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q00LT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (70)
1 – 10 of 70
SLC4A3
Tbio
Family: Transporter
Novelty: 0.04796224
Score: 0.715
Data Source: STRINGDB
PDE6A
Tclin
Family: Enzyme
Novelty: 0.02680494
Score: 0.686
Data Source: STRINGDB
PCARE
Tbio
Novelty: 0.0915146
Score: 0.68
Data Source: STRINGDB
CNGB1
Tbio
Family: IC
Novelty: 0.01034916
Score: 0.669
Data Source: STRINGDB
IMPG2
Tbio
Novelty: 0.05514955
Score: 0.668
Data Source: STRINGDB
ZNF513
Tbio
Family: TF
Novelty: 0.86576929
Score: 0.654
Data Source: STRINGDB
PDE6B
Tclin
Family: Enzyme
Novelty: 0.001105
Score: 0.651
Data Source: STRINGDB
RPE65
Tbio
Family: Enzyme
Novelty: 0.00147985
Score: 0.646
Data Source: STRINGDB
CERKL
Tbio
Family: Enzyme
Novelty: 0.04190552
Score: 0.642
Data Source: STRINGDB
FRMD6
Tbio
Novelty: 0.0034642
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.80

PubMed score by year
PubTator Score  6.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer