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Tbio
BEX3
Protein BEX3

Protein Summary
Description
May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361298
  • ENSP00000354843
  • ENSG00000166681
  • ENST00000372634
  • ENSP00000361717
  • ENST00000372635
  • ENSP00000361718
  • ENST00000372645
  • ENSP00000361728

Symbol
  • DXS6984E
  • NADE
  • NGFRAP1
  • Bex
  • NADE
  • HGR74
  • NGFRAP1
  • DXS6984E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.3   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.3   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q00994-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (110)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
NADE modulates death signalling
Reactome
Signal Transduction
Reactome
p75 NTR receptor-mediated signalling
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
NADE modulates death signalling
Signal Transduction
p75 NTR receptor-mediated signalling
Protein-Protein Interactions (32)
1 – 10 of 32
NGFR
Tclin
Novelty: 0.00072052
Score: 0.982
Data Source: Reactome,STRINGDB
CASP2
Tchem
Family: Enzyme
Novelty: 0.00189892
Score: 0.944
Data Source: Reactome,STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
Score: 0.942
Data Source: Reactome,STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.939
Data Source: Reactome,STRINGDB
SORT1
Tchem
Novelty: 0.00319862
Score: 0.927
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.922
Data Source: Reactome,STRINGDB
TCEAL6
Tdark
Novelty: 0.88185411
Score: 0.805
Data Source: STRINGDB
TCEAL7
Tbio
Novelty: 0.14952824
Score: 0.804
Data Source: STRINGDB
TCEAL1
Tbio
Novelty: 0.02210924
Score: 0.759
Data Source: STRINGDB
GPRASP1
Tbio
Novelty: 0.08928484
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.30

PubMed score by year
PubTator Score  63.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer