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Tbio
IRF9
Interferon regulatory factor 9

Protein Summary
Description
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396864
  • ENSP00000380073
  • ENSG00000213928
  • ENST00000646071
  • ENSP00000494792
  • ENSG00000285048

Symbol
  • ISGF3G
  • p48
  • IRF-9
  • ISGF3
  • ISGF3G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.99
gene perturbation
0.99
transcription factor binding site profile
0.88
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.01   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.01   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 9
VGNC:3391
744767
Mouse
MGI:107587
16391
Rat
RGD:1308766
305896
Dog
interferon regulatory factor 9
VGNC:42097
607899
Horse
interferon regulatory factor 9
VGNC:19139
100051589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 9
Mouse
Rat
Dog
interferon regulatory factor 9
Horse
interferon regulatory factor 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q00978-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Interferon gamma signaling
Protein-Protein Interactions (274)
1 – 10 of 274
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RAD18
Tbio
Family:  Enzyme
Novelty:  0.00519213
p_int:  0.999852642
p_ni:  0.000147358
Score:  0.177
Data Source:  BioPlex,STRINGDB
UBE2R2
Tbio
Novelty:  0.29593236
p_int:  0.999077881
p_ni:  0.000004358
p_wrong:  0.00091776
Score:  0.309
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.994755183
p_ni:  0.005244817
Score:  0.172
Data Source:  BioPlex,STRINGDB
FBLN1
Tbio
Novelty:  0.00796703
p_int:  0.9936759
p_ni:  0.0063241
Score:  0.176
Data Source:  BioPlex,STRINGDB
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.992550962
p_ni:  0.007449038
Score:  0.176
Data Source:  BioPlex,STRINGDB
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.87892665
p_ni:  0.12107335
Score:  0.173
Data Source:  BioPlex,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.997
Data Source:  Reactome,STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.993
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.992
Data Source:  STRINGDB
Publication Statistics
PubMed Score  116.01

PubMed score by year
PubTator Score  227.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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