Tclin CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B

Protein Summary

Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q00975
• B1AQK5

Gene Name

• CACNA1B

Ensembl ID

• ENST00000277551
• ENSP00000277551
• ENSG00000148408
• ENST00000371372
• ENSP00000360423

Symbol

• CACH5
• CACNL1A5
• BIII
• CACNN
• DYT23
• Cav2.2
• CACNL1A5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.85
disease perturbation	0.79
virus perturbation	0.79
cellular component	0.68

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1b Subfamily / Voltage-dependent N-type Calcium Channel Subunit Alpha-1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.89   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.89   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 335

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4