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Tclin
CACNA1B
Voltage-dependent N-type calcium channel subunit alpha-1B

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277551
  • ENSP00000277551
  • ENSG00000148408
  • ENST00000371372
  • ENSP00000360423

Symbol
  • CACH5
  • CACNL1A5
  • BIII
  • CACNN
  • DYT23
  • Cav2.2
  • CACNL1A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.85
disease perturbation
0.79
virus perturbation
0.79
cellular component
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.89   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.89   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 335
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4