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Tbio
PSG6
Pregnancy-specific beta-1-glycoprotein 6

Protein Summary
Description
This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000187910
  • ENSP00000187910
  • ENSG00000170848
  • ENST00000292125
  • ENSP00000292125

Symbol
  • CGM3
  • PSG10
  • PSG12
  • PSGGB
  • PSG10
  • PSGGB
  • PSBG-6
  • PSBG-10
  • PSBG-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.8
protein domain
0.73
small molecule perturbation
0.44
chemical
0.41
virus perturbation
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
31.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q00889-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (10)
1 – 10 of 10
SDC2
Tbio
Novelty:  0.00597758
Score:  0.917
Data Source:  STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.9
Data Source:  STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.9
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.9
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.9
Data Source:  STRINGDB
SDC3
Tbio
Novelty:  0.01095269
Score:  0.9
Data Source:  STRINGDB
PSG4
Tbio
Novelty:  0.09464871
Score:  0.567
Data Source:  STRINGDB
PSG3
Tbio
Novelty:  0.05846466
Score:  0.559
Data Source:  STRINGDB
PSG1
Tbio
Novelty:  0.0239046
Score:  0.508
Data Source:  STRINGDB
CCDC198
Tdark
Novelty:  0.77518585
Score:  0.457
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.08

PubMed score by year
PubTator Score  8.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer