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Tchem
SORD
Sorbitol dehydrogenase

Protein Summary
Description
Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267814
  • ENSP00000267814
  • ENSG00000140263
  • ENST00000558789
  • ENSP00000453904

Symbol
  • SORD1
  • HEL-S-95n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
virus perturbation
0.92
histone modification site profile
0.91
disease perturbation
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.98   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 494   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.98   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 494   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Formation of xylulose-5-phosphate (R-HSA-5661270)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of xylulose-5-phosphate
Reactome
Fructose biosynthesis
Reactome
Fructose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Formation of xylulose-5-phosphate
Fructose biosynthesis
Fructose metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (138)
1 – 10 of 138
SPATA1
Tdark
p_int: 0.985349756
p_ni: 0.014650244
Data Source: BioPlex
PRR11
Tbio
Novelty: 0.05796701
p_int: 0.946589475
p_ni: 0.053410525
Score: 0.163
Data Source: BioPlex,STRINGDB
AKR1B1
Tclin
Family: Enzyme
Novelty: 0.00050572
Score: 0.996
Data Source: STRINGDB
HK1
Tchem
Family: Kinase
Novelty: 0.00089993
Score: 0.956
Data Source: STRINGDB
KHK
Tchem
Family: Kinase
Novelty: 0.01116139
Score: 0.956
Data Source: STRINGDB
AKR1B10
Tchem
Family: Enzyme
Novelty: 0.00276847
Score: 0.956
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00022628
Score: 0.948
Data Source: STRINGDB
HK2
Tchem
Family: Kinase
Novelty: 0.00222818
Score: 0.922
Data Source: STRINGDB
DCXR
Tbio
Family: Enzyme
Novelty: 0.00064186
Score: 0.918
Data Source: STRINGDB
HKDC1
Tbio
Family: Kinase
Novelty: 0.02926931
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  177.98

PubMed score by year
PubTator Score  84.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer