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Tbio
REEP5
Receptor expression-enhancing protein 5

Protein Classes
Protein Summary
Description
May promote functional cell surface expression of olfactory receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379638
  • ENSP00000368959
  • ENSG00000129625

Symbol
  • C5orf18
  • DP1
  • TB2
  • DP1
  • TB2
  • YOP1
  • Yip2e
  • D5S346
  • C5orf18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
kinase perturbation
0.99
virus perturbation
0.92
transcription factor binding site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.07   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.07   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reaction time measurement
1
2
2
27.2
bone density
1
1
1
21.9
worry measurement
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reaction time measurement
2
27.2
bone density
1
21.9
worry measurement
1
5.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 5
VGNC:4146
737918
Macaque
receptor accessory protein 5
100424914
Mouse
MGI:1270152
13476
Rat
RGD:1306047
364838
Dog
receptor accessory protein 5
VGNC:45464
479137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 5
Macaque
receptor accessory protein 5
Mouse
Rat
Dog
receptor accessory protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q00765-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (516)
1 – 10 of 516
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
p_int: 0.999999826
p_ni: 1.74e-7
Score: 0.193
Data Source: BioPlex,STRINGDB
MFN2
Tbio
Novelty: 0.00137876
p_int: 0.99999968
p_ni: 3.18e-7
p_wrong: 1e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
TMEM68
Tdark
Novelty: 0.61508475
p_int: 0.999998186
p_ni: 0.000001814
Score: 0.197
Data Source: BioPlex,STRINGDB
FAM210B
Tbio
Novelty: 0.19704434
p_int: 0.999997155
p_ni: 0.000002824
p_wrong: 2.1e-8
Score: 0.151
Data Source: BioPlex,STRINGDB
REEP6
Tbio
Novelty: 0.10645981
p_int: 0.999986232
p_ni: 0.000013768
Score: 0.657
Data Source: BioPlex,STRINGDB
GALNT16
Tbio
Family: Enzyme
Novelty: 0.34686672
p_int: 0.999972951
p_ni: 0.000027049
Score: 0.162
Data Source: BioPlex,STRINGDB
TMUB2
Tdark
Novelty: 1.76302035
p_int: 0.999959643
p_ni: 0.000040357
Data Source: BioPlex
SOGA3
Tdark
Novelty: 2.17187131
p_int: 0.999874381
p_ni: 0.00012554
p_wrong: 7.9e-8
Score: 0.192
Data Source: BioPlex,STRINGDB
PLSCR1
Tbio
Family: Enzyme
Novelty: 0.01483138
p_int: 0.999745384
p_ni: 0.000254574
p_wrong: 4.2e-8
Score: 0.369
Data Source: BioPlex,STRINGDB
GALNT7
Tbio
Family: Enzyme
Novelty: 0.05328171
p_int: 0.99952038
p_ni: 0.00047962
Data Source: BioPlex
Publication Statistics
PubMed Score  555.07

PubMed score by year
PubTator Score  76.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer