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Tbio
PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Protein Classes
Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260402
  • ENSP00000260402
  • ENSG00000137841
  • ENST00000456256
  • ENSP00000411991
  • ENST00000557821
  • ENSP00000453975

Symbol
  • PLC-beta-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
metabolite
0.89
pathway
0.89
tissue sample
0.72
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.75   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.75   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
84.4
1
1
0
100
71.2
myeloid white cell count
1
1
1
45.1
neutrophil count
2
1
2
41.8
Ischemic stroke
1
1
0
14.3
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
84.4
0
100
71.2
myeloid white cell count
1
45.1
neutrophil count
2
41.8
Ischemic stroke
0
14.3
34.8
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (132)
Acetylcholine regulates insulin secretion (R-HSA-399997)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Activation of kainate receptors upon glutamate binding
Beta-catenin independent WNT signaling
Ca2+ pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Protein-Protein Interactions (343)
1 – 10 of 343
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.982
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.978
Data Source: Reactome,STRINGDB
GNB4
Tbio
Novelty: 0.08250797
Score: 0.963
Data Source: STRINGDB
ITPR3
Tchem
Family: IC
Novelty: 0.00154917
Score: 0.962
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
Score: 0.961
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.956
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.953
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.953
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.953
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.949
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  174.75

PubMed score by year
PubTator Score  98.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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