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Tbio
FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

Protein Summary
Description
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216330
  • ENSP00000216330
  • ENSG00000100442
  • ENST00000396062
  • ENSP00000379374

Symbol
  • FKBP25
  • FKBP-3
  • FKBP25
  • PPIase
  • FKBP-25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
disease perturbation
0.79
transcription factor perturbation
0.74
tissue sample
0.7
tissue
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.76   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.76   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 3
VGNC:3423
452883
Macaque
FK506 binding protein 3
702405
Mouse
MGI:1353460
30795
Rat
RGD:1304992
299104
Dog
FK506 binding protein 3
VGNC:50526
480306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 3
Macaque
FK506 binding protein 3
Mouse
Rat
Dog
FK506 binding protein 3
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q00688-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (100)
1 – 10 of 100
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.958
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.954
Data Source: STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.9
Data Source: STRINGDB
LARP6
Tbio
Novelty: 0.06933013
Score: 0.876
Data Source: STRINGDB
RTRAF
Tbio
Novelty: 0.03996206
Score: 0.765
Data Source: STRINGDB
YY1
Tbio
Family: TF
Novelty: 0.00120891
Score: 0.757
Data Source: STRINGDB
PSMA3
Tbio
Family: Enzyme
Novelty: 0.03106507
Score: 0.733
Data Source: STRINGDB
PIN1
Tchem
Family: Enzyme
Novelty: 0.00957198
Score: 0.718
Data Source: STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
Score: 0.715
Data Source: STRINGDB
PIN4
Tbio
Family: Enzyme
Novelty: 0.01193983
Score: 0.697
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.76

PubMed score by year
PubTator Score  36.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer