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Tchem
NFKB2
Nuclear factor NF-kappa-B p100 subunit

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000189444
  • ENSP00000189444
  • ENSG00000077150
  • ENST00000369966
  • ENSP00000358983
  • ENST00000428099
  • ENSP00000410256

Symbol
  • LYT10
  • p52
  • p100
  • H2TF1
  • LYT10
  • CVID10
  • LYT-10
  • NF-kB2
  • p49/p100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
biological process
0.93
virus perturbation
0.92
molecular function
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.28   (req: < 5)
Gene RIFs: 114   (req: <= 3)
Antibodies: 903   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.28   (req: >= 5)
Gene RIFs: 114   (req: > 3)
Antibodies: 903   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1