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Tchem
NFKB2
Nuclear factor NF-kappa-B p100 subunit

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000189444
  • ENSP00000189444
  • ENSG00000077150
  • ENST00000369966
  • ENSP00000358983
  • ENST00000428099
  • ENSP00000410256

Symbol
  • LYT10
  • p52
  • p100
  • H2TF1
  • LYT10
  • CVID10
  • LYT-10
  • NF-kB2
  • p49/p100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
biological process
0.93
virus perturbation
0.92
molecular function
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.79   (req: < 5)
Gene RIFs: 114   (req: <= 3)
Antibodies: 903   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.79   (req: >= 5)
Gene RIFs: 114   (req: > 3)
Antibodies: 903   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bortezomib
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor kappa B subunit 2
VGNC:10454
450697
Macaque
nuclear factor kappa B subunit 2
714689
Mouse
MGI:1099800
18034
Rat
RGD:1307189
309452
Dog
nuclear factor kappa B subunit 2
VGNC:43781
486858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor kappa B subunit 2
Macaque
nuclear factor kappa B subunit 2
Mouse
Rat
Dog
nuclear factor kappa B subunit 2
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (91)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Chromatin modifying enzymes
Chromatin organization
Cytokine Signaling in Immune system
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (257)
1 – 10 of 257
RELB
Tbio
Family: TF
Novelty: 0.00216805
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
REL
Tbio
Family: TF
Novelty: 0.00038265
p_int: 0.999999979
p_ni: 2.1e-8
Score: 0.971
Data Source: BioPlex,STRINGDB
NFKBIA
Tchem
Novelty: 0.00022873
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
NFKBIB
Tbio
Novelty: 0.00517222
p_int: 0.999996888
p_ni: 0.000003112
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.999513731
p_ni: 0.000486237
p_wrong: 3.3e-8
Data Source: BioPlex
NFKBID
Tbio
Novelty: 0.04272718
p_int: 0.99873111
p_ni: 0.00126889
Score: 0.828
Data Source: BioPlex,STRINGDB
DEF6
Tbio
Novelty: 0.0378487
p_int: 0.998590833
p_ni: 0.001409167
Score: 0.215
Data Source: BioPlex,STRINGDB
PADI3
Tchem
Family: Enzyme
Novelty: 0.01110139
p_int: 0.987863184
p_ni: 0.012136815
Score: 0.173
Data Source: BioPlex,STRINGDB
ASB2
Tbio
Novelty: 0.02852942
p_int: 0.979411089
p_ni: 0.020588905
p_wrong: 6e-9
Score: 0.345
Data Source: BioPlex,STRINGDB
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.978263576
p_ni: 0.021736424
p_wrong: 1e-9
Score: 0.61
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  261.79

PubMed score by year
PubTator Score  367.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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