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Tchem
HSF1
Heat shock factor protein 1

Protein Summary
Description
Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528838
  • ENSP00000431512
  • ENSG00000185122
  • ENST00000646252
  • ENSP00000493830
  • ENSG00000284774

Symbol
  • HSTF1
  • HSTF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
1
biological term
0.95
biological process
0.93
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.46   (req: < 5)
Gene RIFs: 230   (req: <= 3)
Antibodies: 1600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.46   (req: >= 5)
Gene RIFs: 230   (req: > 3)
Antibodies: 1600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1.1
88.1
alkaline phosphatase measurement
1
1
1
86.2
vital capacity
1
1
1
73.3
forced expiratory volume
1
1
1
70.2
HbA1c measurement
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
88.1
alkaline phosphatase measurement
1
86.2
vital capacity
1
73.3
forced expiratory volume
1
70.2
HbA1c measurement
1
66.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
heat shock transcription factor 1
714078
Mouse
MGI:96238
15499
Rat
RGD:620913
79245
Dog
heat shock transcription factor 1
VGNC:41814
475124
Horse
heat shock transcription factor 1
VGNC:18892
100063350
Species
Name
OMA
EggNOG
Inparanoid
Macaque
heat shock transcription factor 1
Mouse
Rat
Dog
heat shock transcription factor 1
Horse
heat shock transcription factor 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q00613-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (276)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Gene Ontology Terms (85)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (146)
1 – 10 of 146
HSF2
Tbio
Family:  TF
Novelty:  0.06458223
p_int:  0.99999995
p_ni:  5e-8
Score:  0.865
Data Source:  BioPlex,STRINGDB
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.999993563
p_ni:  0.000006436
p_wrong:  1e-9
Score:  0.683
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.99998756
p_ni:  0.000012437
p_wrong:  3e-9
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.99997066
p_ni:  0.000029311
p_wrong:  2.9e-8
Score:  0.626
Data Source:  BioPlex,STRINGDB
LURAP1L
Tdark
Novelty:  2.32630524
p_int:  0.999925924
p_ni:  0.000073776
p_wrong:  3.01e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.996
Data Source:  Reactome,STRINGDB
DNAJB1
Tbio
Novelty:  0.00139956
Score:  0.99
Data Source:  Reactome,STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
Score:  0.986
Data Source:  Reactome,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.986
Data Source:  Reactome,STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.986
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  258.46

PubMed score by year
PubTator Score  573.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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