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Tbio
CLTC
Clathrin heavy chain 1

Protein Summary
Description
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by Re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269122
  • ENSP00000269122
  • ENSG00000141367
  • ENST00000393043
  • ENSP00000376763

Symbol
  • CLH17
  • CLTCL2
  • KIAA0034
  • Hc
  • CHC
  • CHC17
  • MRD56
  • CLH-17
  • CLTCL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
transcription factor binding site profile
0.98
protein domain
0.97


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.35   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.35   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
clathrin heavy chain
VGNC:9237
455168
Mouse
MGI:2388633
67300
Rat
RGD:2364
54241
Dog
clathrin heavy chain
VGNC:39367
480578
Horse
clathrin heavy chain
VGNC:16641
100057364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
clathrin heavy chain
Mouse
Rat
Dog
clathrin heavy chain
Horse
clathrin heavy chain
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q00610-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (59)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Gene Ontology Terms (51)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
FlyBase
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (453)
1 – 10 of 453
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.975383081
p_ni: 0.024616919
Score: 0.368
Data Source: BioPlex,STRINGDB
C10orf88
Tdark
Novelty: 0.49807003
p_int: 0.831545855
p_ni: 0.168454145
Score: 0.21
Data Source: BioPlex,STRINGDB
CLTB
Tbio
Novelty: 0.00931222
Score: 0.997
Data Source: Reactome,STRINGDB
CLTA
Tbio
Novelty: 0.01900315
Score: 0.997
Data Source: Reactome,STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
Score: 0.996
Data Source: STRINGDB
DNAJC6
Tbio
Family: Enzyme
Novelty: 0.01359669
Score: 0.996
Data Source: STRINGDB
SNAP91
Tbio
Novelty: 0.0083886
Score: 0.993
Data Source: STRINGDB
ARRB1
Tbio
Novelty: 0.00262758
Score: 0.992
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.991
Data Source: STRINGDB
HGS
Tbio
Family: Enzyme
Novelty: 0.00665044
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  325.35

PubMed score by year
PubTator Score  133.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer