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Tbio
CDC42EP1
Cdc42 effector protein 1

Protein Summary
Description
Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249014
  • ENSP00000249014
  • ENSG00000128283

Symbol
  • BORG5
  • CEP1
  • MSE55
  • CEP1
  • BORG5
  • MSE55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
PubMedID
0.86
transcription factor binding site profile
0.86
ligand (protein) perturbation
0.83
virus perturbation
0.79


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDC42 effector protein 1
VGNC:12826
458813
Macaque
CDC42 effector protein 1
697553
Mouse
MGI:1929763
104445
Rat
RGD:1311131
315121
Dog
CDC42 effector protein 1
VGNC:39000
481267
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDC42 effector protein 1
Macaque
CDC42 effector protein 1
Mouse
Rat
Dog
CDC42 effector protein 1
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (14)
1 – 10 of 14
RHOQ
Tbio
Family: Enzyme
Novelty: 0.00562425
Score: 0.664
Data Source: STRINGDB
SYBU
Tbio
Novelty: 0.06029092
Score: 0.644
Data Source: STRINGDB
TLE6
Tbio
Novelty: 0.07734594
Score: 0.64
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.604
Data Source: STRINGDB
USHBP1
Tbio
Novelty: 0.12829949
Score: 0.584
Data Source: STRINGDB
COX6B2
Tbio
Family: Enzyme
Novelty: 0.1103017
Score: 0.557
Data Source: STRINGDB
ARHGEF17
Tbio
Novelty: 0.03360149
Score: 0.508
Data Source: STRINGDB
SYDE2
Tdark
Family: Enzyme
Novelty: 1.77288781
Score: 0.491
Data Source: STRINGDB
FSCN2
Tbio
Novelty: 0.04059985
Score: 0.463
Data Source: STRINGDB
HS3ST2
Tbio
Family: Enzyme
Novelty: 0.0611326
Score: 0.461
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.91

PubMed score by year
PubTator Score  7.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer