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Tbio
PURA
Transcriptional activator protein Pur-alpha

Protein Summary
Description
This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331327
  • ENSP00000332706
  • ENSG00000185129

Symbol
  • PUR1
  • PUR1
  • MRD31
  • PURALPHA
  • PUR-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
molecular function
0.91
PubMedID
0.89
transcription factor perturbation
0.88
transcription factor binding site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.01   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.01   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Exercise-induced Circadian Regulation
WikiPathways
Exercise-induced Circadian Regulation
WikiPathways
NRF2 pathway
WikiPathways
Metapathway biotransformation Phase I and II
Name
Explore in Pharos
Explore in Source
Exercise-induced Circadian Regulation
Exercise-induced Circadian Regulation
NRF2 pathway
Metapathway biotransformation Phase I and II
Gene Ontology Terms (26)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (79)
1 – 10 of 79
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.832620881
p_ni: 0.167379119
Data Source: BioPlex
ZCRB1
Tdark
Novelty: 0.37592387
p_int: 0.827575019
p_ni: 0.172424981
Score: 0.59
Data Source: BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty: 0.01125284
p_int: 0.809595193
p_ni: 0.190404807
Score: 0.195
Data Source: BioPlex,STRINGDB
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.789046357
p_ni: 0.210953643
Score: 0.307
Data Source: BioPlex,STRINGDB
PURB
Tbio
Novelty: 0.02303518
Score: 0.983
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.894
Data Source: STRINGDB
GNPTAB
Tbio
Family: Enzyme
Novelty: 0.00336101
Score: 0.86
Data Source: STRINGDB
POLA1
Tclin
Family: Enzyme
Novelty: 0.0039096
Score: 0.824
Data Source: STRINGDB
RFC3
Tbio
Novelty: 0.02712951
Score: 0.823
Data Source: STRINGDB
MDH2
Tchem
Family: Enzyme
Novelty: 0.00217694
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.01

PubMed score by year
PubTator Score  113.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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