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Tchem
CDK17
Cyclin-dependent kinase 17

Protein Summary
Description
May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261211
  • ENSP00000261211
  • ENSG00000059758
  • ENST00000543119
  • ENSP00000444459

Symbol
  • PCTAIRE2
  • PCTK2
  • PCTK2
  • PCTAIRE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
0.94
transcription factor binding site profile
0.88
microRNA
0.83
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
36.7
eosinophil count
2
1
2
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
36.7
eosinophil count
2
6.8
Protein-Protein Interactions (129)
1 – 10 of 129
CDK16
Tchem
Family: Kinase
Novelty: 0.02579684
p_int: 1
Score: 0.205
Data Source: BioPlex,STRINGDB
PPP2R3A
Tbio
Family: Enzyme
Novelty: 0.0350873
p_int: 0.999847649
p_ni: 0.000113662
p_wrong: 0.000038688
Score: 0.312
Data Source: BioPlex,STRINGDB
PFDN2
Tbio
Novelty: 0.08537716
p_int: 0.9973688
p_ni: 0.0026312
Score: 0.158
Data Source: BioPlex,STRINGDB
TDRD7
Tbio
Family: Epigenetic
Novelty: 0.03580848
p_int: 0.991106077
p_ni: 0.000177221
p_wrong: 0.008716702
Score: 0.891
Data Source: BioPlex,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
p_int: 0.990313153
p_ni: 0.009686847
Score: 0.152
Data Source: BioPlex,STRINGDB
UNC45A
Tbio
Novelty: 0.07503761
p_int: 0.986713176
p_ni: 0.013286822
p_wrong: 2e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
PPP2R5E
Tbio
Family: Enzyme
Novelty: 0.05974697
p_int: 0.980413062
p_ni: 0.019586922
p_wrong: 1.6e-8
Score: 0.258
Data Source: BioPlex,STRINGDB
FEM1A
Tbio
Novelty: 0.10983638
p_int: 0.975022921
p_ni: 4.9e-7
p_wrong: 0.024976588
Score: 0.595
Data Source: BioPlex,STRINGDB
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.949215491
p_ni: 0.050769749
p_wrong: 0.00001476
Data Source: BioPlex
SUGP1
Tbio
Novelty: 0.00434166
p_int: 0.944295096
p_ni: 0.0557045
p_wrong: 4.05e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.32

PubMed score by year
PubTator Score  1.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer