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Tchem
CDK16
Cyclin-dependent kinase 16

Protein Summary
Description
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276052
  • ENSP00000276052
  • ENSG00000102225
  • ENST00000357227
  • ENSP00000349762
  • ENST00000457458
  • ENSP00000405798
  • ENST00000518022
  • ENSP00000429751

Symbol
  • PCTAIRE1
  • PCTK1
  • PCTK1
  • PCTAIRE
  • PCTAIRE1
  • PCTGAIRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
0.94
transcription factor
0.81
kinase
0.8
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.04   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.04   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (127)
1 – 10 of 127
CDK17
Tchem
Family: Kinase
Novelty: 0.25046297
p_int: 1
Score: 0.205
Data Source: BioPlex,STRINGDB
CDK18
Tchem
Family: Kinase
Novelty: 0.053383
p_int: 0.999999962
p_ni: 1.1e-8
p_wrong: 2.7e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
CCNYL1
Tdark
Novelty: 0.45350824
p_int: 0.99998541
p_ni: 0.00001459
Score: 0.931
Data Source: BioPlex,STRINGDB
ICK
Tchem
Family: Kinase
Novelty: 0.00810476
p_int: 0.999953568
p_ni: 5e-9
p_wrong: 0.000046427
Score: 0.42
Data Source: BioPlex,STRINGDB
NUP54
Tbio
Novelty: 0.08155008
p_int: 0.999634532
p_ni: 0.000365468
Score: 0.159
Data Source: BioPlex,STRINGDB
CDK8
Tchem
Family: Kinase
Novelty: 0.00508026
p_int: 0.998481201
p_ni: 0.001518799
Score: 0.328
Data Source: BioPlex,STRINGDB
CCNY
Tbio
Novelty: 0.01400663
p_int: 0.99375203
p_ni: 0.000236503
p_wrong: 0.006011467
Score: 0.962
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.960188595
p_ni: 0.039811405
Score: 0.517
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.926752429
p_ni: 0.073247571
Score: 0.314
Data Source: BioPlex,STRINGDB
GTF2F1
Tbio
Novelty: 0.02118098
p_int: 0.890592296
p_ni: 0.109407626
p_wrong: 7.8e-8
Score: 0.213
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  48.04

PubMed score by year
PubTator Score  21.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer