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Tchem
CDK5
Cyclin-dependent-like kinase 5

Protein Summary
Description
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297518
  • ENSP00000297518
  • ENSG00000164885
  • ENST00000485972
  • ENSP00000419782

Symbol
  • CDKN5
  • LIS7
  • PSSALRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
hub protein
0.99
biological term
0.93
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1683.25   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 929   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1683.25   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 929   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 89
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (312)
FIBP
Tbio
Novelty:  0.11312115
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.778
Data Source:  BioPlex,STRINGDB
C2CD5
Tbio
Novelty:  0.40144687
p_int:  0.999993395
p_ni:  0.000006605
Score:  0.702
Data Source:  BioPlex,STRINGDB
CABLES1
Tbio
Novelty:  0.04822454
p_int:  0.999953923
p_ni:  0.000046071
p_wrong:  6e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
CCNI2
Tdark
Novelty:  0.6093503
p_int:  0.999936127
p_ni:  0.000063872
p_wrong:  1e-9
Score:  0.431
Data Source:  BioPlex,STRINGDB
CDK5R1
Tchem
Family:  Enzyme
Novelty:  0.01065962
p_int:  0.999904453
p_ni:  0.000095546
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
p_int:  0.999874497
p_ni:  0.000125503
Score:  0.962
Data Source:  BioPlex,STRINGDB
CDK20
Tbio
Family:  Kinase
Novelty:  0.01176977
p_int:  0.999849091
p_ni:  8e-9
p_wrong:  0.000150901
Score:  0.29
Data Source:  BioPlex,STRINGDB
CCNI
Tbio
Novelty:  0.01655153
p_int:  0.999339841
p_ni:  0.000660158
p_wrong:  1e-9
Score:  0.625
Data Source:  BioPlex,STRINGDB
CCND1
Tchem
Novelty:  0.0001186
p_int:  0.998468706
p_ni:  0.001531294
Score:  0.748
Data Source:  BioPlex,STRINGDB
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.996607531
p_ni:  0.003392469
Score:  0.696
Data Source:  BioPlex,STRINGDB
Pathways (52)
Activated NTRK2 signals through CDK5 (R-HSA-9032845)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through CDK5
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
DARPP-32 events
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through CDK5
Axon guidance
CRMPs in Sema3A signaling
DARPP-32 events
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (112)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
4
4
0
1.7
95.8
electrocardiography
2
2
30
11.9
95
appendicular lean mass
3
5
5
93.9
diastolic blood pressure
3
2
3
90.6
5
1
3
1.1
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.7
95.8
electrocardiography
30
11.9
95
appendicular lean mass
5
93.9
diastolic blood pressure
3
90.6
3
1.1
89.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 5
VGNC:7364
463891
Macaque
cyclin dependent kinase 5
714445
Mouse
MGI:101765
12568
Rat
RGD:70514
140908
Dog
cyclin dependent kinase 5
VGNC:51795
475537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 5
Macaque
cyclin dependent kinase 5
Mouse
Rat
Dog
cyclin dependent kinase 5
Publication Statistics
PubMed Score 1683.25
PubMed score by year
PubTator Score 810.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title