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Tbio
GTF2B
Transcription initiation factor IIB

Protein Summary
Description
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-indepe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370500
  • ENSP00000359531
  • ENSG00000137947

Symbol
  • TF2B
  • TFIIB
  • TF2B
  • TFIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
disease perturbation
0.9
virus
0.89
transcription factor binding site profile
0.86
hub protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.29   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.29   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (319)
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.999973823
p_ni:  0.000026177
Data Source:  BioPlex
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999949419
p_ni:  0.000047327
p_wrong:  0.000003253
Score:  0.193
Data Source:  BioPlex,STRINGDB
CST1
Tbio
Novelty:  0.02399609
p_int:  0.999729722
p_ni:  0.000270161
p_wrong:  1.17e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.999668188
p_ni:  0.000331802
p_wrong:  1e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
CST4
Tbio
Novelty:  0.00773554
p_int:  0.997693703
p_ni:  0.002301692
p_wrong:  0.000004605
Data Source:  BioPlex
PRB2
Tdark
Novelty:  0.00717114
p_int:  0.996310682
p_ni:  0.000001586
p_wrong:  0.003687732
Data Source:  BioPlex
IGHA1
Tbio
p_int:  0.99335593
p_ni:  0.006644067
p_wrong:  4e-9
Data Source:  BioPlex
SERPINB1
Tbio
Family:  Enzyme
Novelty:  0.00267786
p_int:  0.983419088
p_ni:  0.016573208
p_wrong:  0.000007704
Score:  0.196
Data Source:  BioPlex,STRINGDB
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.979964692
p_ni:  0.020035307
Data Source:  BioPlex
OXSM
Tbio
Family:  Enzyme
Novelty:  0.00615894
p_int:  0.963482236
p_ni:  0.036480067
p_wrong:  0.000037697
Score:  0.203
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Reactome
HIV Transcription Initiation
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
HIV Infection
HIV Life Cycle
HIV Transcription Initiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
77.8
aspartate aminotransferase measurement
1
1
1
73.2
serum alanine aminotransferase measurement
1
1
1
65.9
BMI-adjusted waist circumference
2
2
2
61.8
hemoglobin measurement
2
2
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
77.8
aspartate aminotransferase measurement
1
73.2
serum alanine aminotransferase measurement
1
65.9
BMI-adjusted waist circumference
2
61.8
hemoglobin measurement
2
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIB
VGNC:1255
743356
Macaque
general transcription factor IIB
694770
Mouse
MGI:2385191
229906
Rat
RGD:619735
81673
Dog
general transcription factor IIB
VGNC:41543
479960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIB
Macaque
general transcription factor IIB
Mouse
Rat
Dog
general transcription factor IIB
Publication Statistics
PubMed Score 523.29
PubMed score by year
PubTator Score 208.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title