Tbio HDLBP Vigilin

Protein Summary

Description

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q00341
• B4DTQ2
• E7EM71
• Q53QU2
• Q9UCY3

Gene Name

• HDLBP

Ensembl ID

• ENST00000427183
• ENSP00000399139
• ENSG00000115677

Symbol

• HBP
• VGL
• HBP
• VGL
• PRO2900

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
transcription factor perturbation	1
kinase perturbation	0.96
transcription factor binding site profile	0.96

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.79   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.79   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0