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Tbio
MAT1A
S-adenosylmethionine synthase isoform type-1

Protein Summary
Description
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372213
  • ENSP00000361287
  • ENSG00000151224

Symbol
  • AMS1
  • MATA1
  • MAT
  • SAMS
  • MATA1
  • SAMS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
disease perturbation
0.83
gene perturbation
0.73
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.35   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.35   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
2
3
85.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
85.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
methionine adenosyltransferase 1A
700519
Mouse
MGI:88017
11720
Rat
RGD:3050
25331
Dog
methionine adenosyltransferase 1A
VGNC:43037
608788
Horse
methionine adenosyltransferase 1A
VGNC:19993
100052797
Species
Name
OMA
EggNOG
Inparanoid
Macaque
methionine adenosyltransferase 1A
Mouse
Rat
Dog
methionine adenosyltransferase 1A
Horse
methionine adenosyltransferase 1A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q00266-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Metabolic disorders of biological oxidation enzymes
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Disease
Diseases of metabolism
Metabolic disorders of biological oxidation enzymes
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (122)
1 – 10 of 122
MAT2A
Tbio
Family: Enzyme
Novelty: 0.00667707
p_int: 1
Score: 0.988
Data Source: BioPlex,STRINGDB
MAT2B
Tbio
Family: Enzyme
Novelty: 0.04553044
p_int: 0.999407323
p_ni: 0.000592677
Score: 0.996
Data Source: BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty: 0.01172319
p_int: 0.958196185
p_ni: 0.041803813
p_wrong: 1e-9
Score: 0.28
Data Source: BioPlex,STRINGDB
BHMT
Tchem
Family: Enzyme
Novelty: 0.00453508
Score: 0.978
Data Source: STRINGDB
MTR
Tbio
Family: Enzyme
Novelty: 0.0006987
Score: 0.976
Data Source: STRINGDB
BHMT2
Tchem
Family: Enzyme
Novelty: 0.07713739
Score: 0.964
Data Source: STRINGDB
AMD1
Tchem
Family: Enzyme
Novelty: 0.00231813
Score: 0.961
Data Source: STRINGDB
DNMT1
Tclin
Family: Enzyme
Novelty: 0.00042336
Score: 0.955
Data Source: STRINGDB
DNMT3B
Tchem
Family: Epigenetic
Novelty: 0.00118766
Score: 0.931
Data Source: STRINGDB
DNMT3A
Tclin
Family: Epigenetic
Novelty: 0.00085974
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  263.35

PubMed score by year
PubTator Score  464.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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