Tbio PITPNA Phosphatidylinositol transfer protein alpha isoform

Protein Summary

Description

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q00169
• PI-TP-alpha

Gene Name

• PITPNA

Ensembl ID

• ENST00000313486
• ENSP00000316809
• ENSG00000174238

Symbol

• PITPN
• PITPN
• VIB1A
• HEL-S-36
• PI-TPalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.95
interacting protein	0.87
metabolite	0.86
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Transporter / Phosphatidylinositol Transfer Protein Alpha Isoform

Protein / Transfer/carrier Protein / Phosphatidylinositol Transfer Protein Alpha Isoform

DTO Classes

Protein / Transporter / Phosphatidylinositol Transfer Protein Alpha Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.7   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.7   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0