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Tbio
TFAM
Transcription factor A, mitochondrial

Protein Summary
Description
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373895
  • ENSP00000363002
  • ENSG00000108064
  • ENST00000487519
  • ENSP00000420588

Symbol
  • TCF6
  • TCF6L2
  • TCF6
  • MTTF1
  • MTTFA
  • TCF6L1
  • TCF6L2
  • TCF6L3
  • MTDPS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.93
histone modification site profile
0.89
transcription factor perturbation
0.84
transcription factor binding site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 762.19   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 495   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 762.19   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
2
2
2
40.9
heel bone mineral density
1
1
1
40.4
Abnormality of refraction
1
1
1
20.3
Agents acting on the renin-angiotensin system use measurement
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
2
40.9
heel bone mineral density
1
40.4
Abnormality of refraction
1
20.3
Agents acting on the renin-angiotensin system use measurement
1
0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor A, mitochondrial
VGNC:12509
466079
Macaque
transcription factor A, mitochondrial
701368
Mouse
MGI:107810
21780
Rat
RGD:620682
83474
Dog
transcription factor A, mitochondrial
VGNC:47282
488989
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor A, mitochondrial
Macaque
transcription factor A, mitochondrial
Mouse
Rat
Dog
transcription factor A, mitochondrial
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q00059-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial transcription initiation
Reactome
Organelle biogenesis and maintenance
Reactome
Transcription from mitochondrial promoters
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Mitochondrial biogenesis
Mitochondrial transcription initiation
Organelle biogenesis and maintenance
Transcription from mitochondrial promoters
Gene Ontology Terms (19)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (181)
1 – 10 of 181
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.888877293
p_ni: 0.111122707
Score: 0.237
Data Source: BioPlex,STRINGDB
POLRMT
Tbio
Family: Enzyme
Novelty: 0.01398067
Score: 0.999
Data Source: Reactome,STRINGDB
TFB2M
Tbio
Family: Enzyme
Novelty: 0.02345237
Score: 0.998
Data Source: Reactome,STRINGDB
NRF1
Tbio
Family: TF
Novelty: 0.00543248
Score: 0.993
Data Source: STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.979
Data Source: STRINGDB
GABPA
Tbio
Family: TF
Novelty: 0.01731451
Score: 0.971
Data Source: STRINGDB
PPRC1
Tbio
Novelty: 0.00182088
Score: 0.956
Data Source: STRINGDB
TFB1M
Tbio
Family: Enzyme
Novelty: 0.0236373
Score: 0.953
Data Source: STRINGDB
SSBP1
Tbio
Novelty: 0.01105839
Score: 0.86
Data Source: STRINGDB
POLG
Tchem
Family: Enzyme
Novelty: 0.00172189
Score: 0.858
Data Source: STRINGDB
Publication Statistics
PubMed Score  762.19

PubMed score by year
PubTator Score  389.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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