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Tbio
HOXA4
Homeobox protein Hox-A4

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360046
  • ENSP00000353151
  • ENSG00000197576
  • ENST00000428284
  • ENSP00000408845
  • ENST00000610970
  • ENSP00000479166

Symbol
  • HOX1D
  • HOX1
  • HOX1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
protein domain
0.85
kinase perturbation
0.66
small molecule perturbation
0.56
tissue sample
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.81   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.81   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
61.4
Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (69)
1 – 10 of 69
RNH1
Tbio
Family: Enzyme
Novelty: 0.00307468
p_int: 0.987599187
p_ni: 2e-9
p_wrong: 0.012400812
Data Source: BioPlex
RARB
Tclin
Family: NR
Novelty: 0.00257427
Score: 0.919
Data Source: STRINGDB
RARA
Tclin
Family: NR
Novelty: 0.00080574
Score: 0.918
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.912
Data Source: STRINGDB
POLR2I
Tbio
Family: Enzyme
Novelty: 0.03100605
Score: 0.91
Data Source: STRINGDB
CTCF
Tbio
Family: TF
Novelty: 0.00085923
Score: 0.91
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.905
Data Source: STRINGDB
NCOA3
Tbio
Family: Epigenetic
Novelty: 0.00193529
Score: 0.903
Data Source: STRINGDB
POLR2G
Tbio
Family: Enzyme
Novelty: 0.01235379
Score: 0.9
Data Source: STRINGDB
POLR2K
Tbio
Family: Enzyme
Novelty: 0.06121272
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.81

PubMed score by year
PubTator Score  29.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer