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Tbio
MPP1
55 kDa erythrocyte membrane protein

Protein Summary
Description
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369534
  • ENSP00000358547
  • ENSG00000130830
  • ENST00000393531
  • ENSP00000377165
  • ENST00000413259
  • ENSP00000400155

Symbol
  • DXS552E
  • EMP55
  • MRG1
  • PEMP
  • AAG12
  • EMP55
  • DXS552E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.91
disease perturbation
0.87
kinase perturbation
0.84
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.999999176
p_ni:  8.25e-7
Data Source:  BioPlex
MYH11
Tbio
Novelty:  0.00142474
p_int:  0.999982472
p_ni:  0.000017521
p_wrong:  8e-9
Score:  0.41
Data Source:  BioPlex,STRINGDB
HTT
Tchem
Novelty:  0.00034051
p_int:  0.999537003
p_ni:  0.000462997
Score:  0.206
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.997123933
p_ni:  0.002876065
p_wrong:  2e-9
Data Source:  BioPlex
ZNF287
Tdark
Family:  TF
Novelty:  1.01445884
p_int:  0.870859124
p_ni:  0.104216918
p_wrong:  0.024923958
Data Source:  BioPlex
COL10A1
Tbio
Novelty:  0.00521991
p_int:  0.862834343
p_ni:  0.135630803
p_wrong:  0.001534854
Score:  0.305
Data Source:  BioPlex,STRINGDB
DMTN
Tbio
Novelty:  0.01330153
Score:  0.735
Data Source:  STRINGDB
GYPC
Tbio
Novelty:  0.00138506
Score:  0.662
Data Source:  STRINGDB
WHRN
Tbio
Novelty:  0.01886351
Score:  0.606
Data Source:  STRINGDB
F8
Tbio
Novelty:  0.0002287
Score:  0.581
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
50.6
hematocrit
1
1
1
50.6
leukocyte count
1
1
1
50.6
erythrocyte count
1
1
1
50.6
lymphocyte percentage of leukocytes
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
50.6
hematocrit
1
50.6
leukocyte count
1
50.6
erythrocyte count
1
50.6
lymphocyte percentage of leukocytes
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
membrane palmitoylated protein 1
702092
Mouse
MGI:105941
17524
Dog
membrane palmitoylated protein 1
VGNC:43342
612626
Horse
membrane palmitoylated protein 1
VGNC:20289
100063094
Cow
membrane palmitoylated protein 1
VGNC:31582
510998
Species
Name
OMA
EggNOG
Inparanoid
Macaque
membrane palmitoylated protein 1
Mouse
Dog
membrane palmitoylated protein 1
Horse
membrane palmitoylated protein 1
Cow
membrane palmitoylated protein 1
Publication Statistics
PubMed Score 10.55
PubMed score by year
PubTator Score 43.45
PubTator score by year
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Related Publications
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PMID
Year
Title