Protein Summary
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
- ENST00000360085
- ENSP00000353198
- ENSG00000131096
- ENST00000592796
- ENSP00000467310
- PYY1
- PYY-I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.8 | ||
PubMedID | 0.64 | ||
disease | 0.59 | ||
gene perturbation | 0.56 | ||
transcription factor perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1726.98 (req: < 5)
Gene RIFs: 97 (req: <= 3)
Antibodies: 427 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1726.98 (req: >= 5)
Gene RIFs: 97 (req: > 3)
Antibodies: 427 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (305)
USP25
Family: Enzyme
Novelty: 0.03671706
p_int: 0.997299766
p_ni: 0.002700179
p_wrong: 5.5e-8
Data Source: BioPlex
XPNPEP3
Family: Enzyme
Novelty: 0.02209842
p_int: 0.975314727
p_ni: 0.024685273
Data Source: BioPlex
BTBD1
Novelty: 0.19772296
p_int: 0.876733668
p_ni: 0.123261075
p_wrong: 0.000005257
Data Source: BioPlex
GLRX
Novelty: 0.00111903
p_int: 0.86261421
p_ni: 0.109878658
p_wrong: 0.027507131
Data Source: BioPlex
PLXDC2
Novelty: 0.06496695
p_int: 0.817284914
p_ni: 0.18271494
p_wrong: 1.46e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (589)
Reactome (7)
KEGG (1)
PathwayCommons (6)
WikiPathways (575)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 3 | 6 | 96.8 | |||||
triglyceride measurement | 2 | 2 | 2 | 69.7 | |||||
sex hormone-binding globulin measurement | 4 | 2 | 4 | 55.2 | |||||
urate measurement | 1 | 1 | 1 | 53.7 | |||||
bone density | 1 | 2 | 2 | 40.3 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 6 | 96.8 | |||||
triglyceride measurement | 2 | 69.7 | |||||
sex hormone-binding globulin measurement | 4 | 55.2 | |||||
urate measurement | 1 | 53.7 | |||||
bone density | 2 | 40.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | peptide YY | VGNC:14186 | 468391 | |||||
Macaque | peptide YY | 714041 | ||||||
Mouse | MGI:99924 | 217212 | ||||||
Rat | RGD:1593289 | 287730 | ||||||
Dog | peptide YY | 607156 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | peptide YY | |||||
Macaque | peptide YY | |||||
Mouse | ||||||
Rat | ||||||
Dog | peptide YY | |||||
Publication Statistics
PubMed Score 1726.98
PubMed score by year
PubTator Score 736.73
PubTator score by year
Related Publications
Text Mined References (120)
GeneRif Annotations (97)
Items per page:
0 of 0
PMID | Year | Title |
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