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Tbio
PYM1
Partner of Y14 and mago

Protein Summary
Description
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398213
  • ENSP00000381271
  • ENSG00000170473
  • ENST00000408946
  • ENSP00000386156

Symbol
  • PYM
  • WIBG
  • PYM
  • WIBG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
MAGOH
Tbio
Novelty:  0.03637008
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
MAD2L1BP
Tbio
Novelty:  0.48374717
p_int:  0.999956955
p_ni:  0.000043039
p_wrong:  6e-9
Score:  0.212
Data Source:  BioPlex,STRINGDB
RBM8A
Tbio
Novelty:  0.00052175
p_int:  0.999701265
p_ni:  0.000298735
Score:  0.999
Data Source:  BioPlex,STRINGDB
CASC3
Tbio
Novelty:  0.03935581
p_int:  0.999682994
p_ni:  0.000317006
Score:  0.956
Data Source:  BioPlex,STRINGDB
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.990431406
p_ni:  0.009568594
Score:  0.666
Data Source:  BioPlex,STRINGDB
DCAF5
Tdark
Novelty:  0.39565074
p_int:  0.970783389
p_ni:  0.029216611
Data Source:  BioPlex
MAD2L1
Tbio
Novelty:  0.01623659
p_int:  0.969685137
p_ni:  0.030314863
Score:  0.325
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.951065632
p_ni:  0.048934368
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.897878399
p_ni:  0.102080021
p_wrong:  0.00004158
Score:  0.254
Data Source:  BioPlex,STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
p_int:  0.873968073
p_ni:  0.126031815
p_wrong:  1.12e-7
Score:  0.588
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
3
3
3.4
97.7
3
3
0
1.3
97.6
asthma
5
4
0
1.1
97.3
type 1 diabetes mellitus
3
2
0
1.3
95.1
educational attainment
2
2
1
56.4
92.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3.4
97.7
0
1.3
97.6
asthma
0
1.1
97.3
type 1 diabetes mellitus
0
1.3
95.1
educational attainment
1
56.4
92.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PYM homolog 1, exon junction complex associated factor
VGNC:5559
451975
Macaque
PYM homolog 1, exon junction complex associated factor
708148
Mouse
MGI:1925678
78428
Dog
PYM homolog 1, exon junction complex associated factor
VGNC:45228
481101
Horse
PYM homolog 1, exon junction complex associated factor
VGNC:22066
100059063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PYM homolog 1, exon junction complex associated factor
Macaque
PYM homolog 1, exon junction complex associated factor
Mouse
Dog
PYM homolog 1, exon junction complex associated factor
Horse
PYM homolog 1, exon junction complex associated factor
Publication Statistics
PubMed Score 37.03
PubMed score by year
PubTator Score 3.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title