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Tbio
PYHIN1
Pyrin and HIN domain-containing protein 1

Protein Summary
Description
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368135
  • ENSP00000357117
  • ENSG00000163564
  • ENST00000368138
  • ENSP00000357120
  • ENST00000368140
  • ENSP00000357122
  • ENST00000392252
  • ENSP00000376082
  • ENST00000392254
  • ENSP00000376083

Symbol
  • IFIX
  • IFIX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
transcription factor perturbation
0.8
tissue sample
0.76
cell line
0.6
tissue
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
TRIM26
Tbio
Novelty:  0.07177119
p_int:  0.999997947
p_ni:  0.000002053
Score:  0.29
Data Source:  BioPlex,STRINGDB
PADI3
Tchem
Family:  Enzyme
Novelty:  0.01110139
p_int:  0.999636764
p_ni:  0.000359703
p_wrong:  0.000003533
Data Source:  BioPlex
CALHM4
Tdark
Family:  IC
Novelty:  2.79788039
p_int:  0.999158103
p_ni:  0.000841809
p_wrong:  8.9e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.998912578
p_ni:  0.00108742
p_wrong:  2e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
CRYBG1
Tbio
Novelty:  0.05471025
p_int:  0.998761515
p_ni:  0.001238478
p_wrong:  7e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.998725124
p_ni:  0.001274862
p_wrong:  1.4e-8
Data Source:  BioPlex
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.997628014
p_ni:  0.002371986
Data Source:  BioPlex
PLCD1
Tchem
Family:  Enzyme
Novelty:  0.00742197
p_int:  0.997515168
p_ni:  0.002476518
p_wrong:  0.000008314
Score:  0.177
Data Source:  BioPlex,STRINGDB
S100A3
Tbio
Novelty:  0.03024004
p_int:  0.996688516
p_ni:  0.001677663
p_wrong:  0.001633821
Score:  0.185
Data Source:  BioPlex,STRINGDB
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.995758418
p_ni:  0.004241582
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
1
1
84
erythrocyte count
1
1
1
83.6
hemoglobin measurement
1
1
1
83.6
hematocrit
1
1
1
83.6
leukocyte count
2
1
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
84
erythrocyte count
1
83.6
hemoglobin measurement
1
83.6
hematocrit
1
83.6
leukocyte count
2
83.6
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyrin and HIN domain family member 1
VGNC:6969
469842
Macaque
pyrin and HIN domain family member 1
719241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyrin and HIN domain family member 1
Macaque
pyrin and HIN domain family member 1
Publication Statistics
PubMed Score 16.70
PubMed score by year
PubTator Score 6.44
PubTator score by year
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Related Publications
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PMID
Year
Title