Tchem PYGL Glycogen phosphorylase, liver form

Protein Summary

Description

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P06737
• A6NDQ4
• B4DUB7
• F5H816
• O60567
• O60752
• O60913
• Q501V9
• Q641R5
• Q96G82

Gene Name

• PYGL

Ensembl ID

• ENST00000216392
• ENSP00000216392
• ENSG00000100504
• ENST00000544180
• ENSP00000443787

Symbol

• GSD6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor perturbation	0.97
PubMedID	0.94
virus perturbation	0.88
gene perturbation	0.86

Protein Classes

PANTHER Classes

Protein / Transferase / Phosphorylase / Glycogen Phosphorylase, Liver Form

DTO Classes

Protein / Enzyme / Transferase / Phosphorylase / Glycogen Phosphorylase, Liver Form

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.99   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 278   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.99   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 372

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0