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Tchem
PYGB
Glycogen phosphorylase, brain form

Protein Summary
Description
Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228). The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216962
  • ENSP00000216962
  • ENSG00000100994

Symbol
  • GPBB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
ligand (protein) perturbation
0.83
interacting protein
0.81
transcription factor perturbation
0.8
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.64   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 569   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.64   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 569   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (212)
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.999830621
p_ni:  0.000169379
Data Source:  BioPlex
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.996381863
p_ni:  0.003618137
Score:  0.56
Data Source:  BioPlex,STRINGDB
TMA16
Tdark
Novelty:  0.89810617
p_int:  0.96199696
p_ni:  0.038003039
Data Source:  BioPlex
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.955176129
p_ni:  0.044823871
Score:  0.191
Data Source:  BioPlex,STRINGDB
CD69
Tchem
Novelty:  0.00056432
p_int:  0.942227204
p_ni:  0.057772795
p_wrong:  1e-9
Score:  0.241
Data Source:  BioPlex,STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  0.914185928
p_ni:  0.085814072
Score:  0.546
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.909890921
p_ni:  0.090109079
Score:  0.173
Data Source:  BioPlex,STRINGDB
NTF3
Tbio
Novelty:  0.00089023
p_int:  0.899326478
p_ni:  0.100673522
Score:  0.201
Data Source:  BioPlex,STRINGDB
HMGN2
Tbio
Novelty:  0.0080343
p_int:  0.865531273
p_ni:  0.134468727
Score:  0.209
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.845373426
p_ni:  0.154626574
Data Source:  BioPlex
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
AMY2A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
CALM2
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
CALM3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
CALM1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
Pathways (31)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Immune System
Innate Immune System
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
3
1
9.7
97
body mass index
2
3
3
82.9
smoking status measurement
2
1
2
71.9
hemoglobin measurement
2
2
2
66.6
hematocrit
2
2
2
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
9.7
97
body mass index
3
82.9
smoking status measurement
2
71.9
hemoglobin measurement
2
66.6
hematocrit
2
63
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glycogen phosphorylase B
705777
Mouse
MGI:97828
110078
Rat
RGD:3460
25739
Dog
glycogen phosphorylase B
VGNC:52899
477003
Horse
glycogen phosphorylase B
VGNC:22061
100057085
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glycogen phosphorylase B
Mouse
Rat
Dog
glycogen phosphorylase B
Horse
glycogen phosphorylase B
Publication Statistics
PubMed Score 448.64
PubMed score by year
PubTator Score 169.56
PubTator score by year
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Related Publications
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PMID
Year
Title