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Tbio
PYDC1
Pyrin domain-containing protein 1

Protein Summary
Description
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302964
  • ENSP00000304336
  • ENSG00000169900

Symbol
  • ASC2
  • ASCI
  • POP1
  • PYC1
  • ASC2
  • POP1
  • PYC1
  • cPOP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
cell line
0.46
tissue sample
0.43
hub protein
0.39
cell type or tissue
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.87   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.87   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0