PYCR1
Pyrroline-5-carboxylate reductase 1, mitochondrial
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.83 | ||
histone modification site profile | 0.83 | ||
kinase perturbation | 0.76 | ||
hub protein | 0.75 | ||
disease perturbation | 0.74 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Glutamate and glutamine metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Glutamate and glutamine metabolism | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 4 | 5 | 75.8 | |||||
vital capacity | 1 | 1 | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 2 | 3 | 3 | 58.3 | |||||
birth weight | 2 | 2 | 2 | 55.2 | |||||
forced expiratory volume | 1 | 1 | 1 | 46.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 5 | 75.8 | |||||
vital capacity | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 3 | 58.3 | |||||
birth weight | 2 | 55.2 | |||||
forced expiratory volume | 1 | 46.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | pyrroline-5-carboxylate reductase 1 | VGNC:12621 | 454977 | |||||
Macaque | pyrroline-5-carboxylate reductase 1 | 715182 | ||||||
Mouse | MGI:2384795 | 209027 | ||||||
Rat | RGD:1307863 | 287877 | ||||||
Dog | pyrroline-5-carboxylate reductase 1 | VGNC:45223 | 483372 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | pyrroline-5-carboxylate reductase 1 | |||||
Macaque | pyrroline-5-carboxylate reductase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pyrroline-5-carboxylate reductase 1 | |||||
PMID | Year | Title |
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