PYCR1
Pyrroline-5-carboxylate reductase 1, mitochondrial
Protein Summary
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
- ENST00000329875
- ENSP00000328858
- ENSG00000183010
- ENST00000337943
- ENSP00000336579
- ENST00000402252
- ENSP00000384949
- ENST00000619204
- ENSP00000479793
- P5C
- P5CR
- PRO3
- PYCR
- PIG45
- PP222
- ARCL2B
- ARCL3B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.83 | ||
histone modification site profile | 0.83 | ||
kinase perturbation | 0.76 | ||
hub protein | 0.75 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 442.34 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 442.34 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (98)
PYCR2
Family: Enzyme
Novelty: 0.05660996
p_int: 0.999999898
p_ni: 1.02e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
KLHDC10
Novelty: 0.40978227
p_int: 0.999990057
p_ni: 0.000009788
p_wrong: 1.55e-7
Score: 0.532
Data Source: BioPlex,STRINGDB
NUDT5
Family: Enzyme
Novelty: 0.02550535
p_int: 0.999714432
p_ni: 0.000285568
Score: 0.94
Data Source: BioPlex,STRINGDB
PYCR3
Family: Enzyme
Novelty: 0.1041757
p_int: 0.925693268
p_ni: 0.074306732
Score: 0.987
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (3)
KEGG (3)
PathwayCommons (5)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glutamate and glutamine metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glutamate and glutamine metabolism | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 4 | 5 | 75.8 | |||||
vital capacity | 1 | 1 | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 2 | 3 | 3 | 58.3 | |||||
birth weight | 2 | 2 | 2 | 55.2 | |||||
forced expiratory volume | 1 | 1 | 1 | 46.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 5 | 75.8 | |||||
vital capacity | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 3 | 58.3 | |||||
birth weight | 2 | 55.2 | |||||
forced expiratory volume | 1 | 46.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pyrroline-5-carboxylate reductase 1 | VGNC:12621 | 454977 | |||||
Macaque | pyrroline-5-carboxylate reductase 1 | 715182 | ||||||
Mouse | MGI:2384795 | 209027 | ||||||
Rat | RGD:1307863 | 287877 | ||||||
Dog | pyrroline-5-carboxylate reductase 1 | VGNC:45223 | 483372 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pyrroline-5-carboxylate reductase 1 | |||||
Macaque | pyrroline-5-carboxylate reductase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pyrroline-5-carboxylate reductase 1 | |||||
Publication Statistics
PubMed Score 442.34
PubMed score by year
PubTator Score 212.74
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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