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Tbio
PXYLP1
2-phosphoxylose phosphatase 1

Protein Summary
Description
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286353
  • ENSP00000286353
  • ENSG00000155893
  • ENST00000393010
  • ENSP00000376733

Symbol
  • ACPL2
  • HEL124
  • XYLP
  • XYLP
  • ACPL2
  • HEL124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.86
transcription factor perturbation
0.84
histone modification site profile
0.83
transcription factor binding site profile
0.82
small molecule perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.999186379
p_ni:  0.00081359
p_wrong:  3.1e-8
Data Source:  BioPlex
LY86
Tbio
Novelty:  0.00314575
p_int:  0.994850179
p_ni:  0.005148025
p_wrong:  0.000001796
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.994354801
p_ni:  0.005641829
p_wrong:  0.00000337
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.994239621
p_ni:  0.005720882
p_wrong:  0.000039498
Score:  0.332
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.994072595
p_ni:  0.005927373
p_wrong:  3.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
KLRC4
Tbio
Novelty:  0.16922525
p_int:  0.977749609
p_ni:  0.021362617
p_wrong:  0.000887774
Data Source:  BioPlex
INS
Tbio
Novelty:  0.00000499
p_int:  0.976147025
p_ni:  0.023591093
p_wrong:  0.000261882
Data Source:  BioPlex
GNPTAB
Tbio
Family:  Enzyme
Novelty:  0.00336101
p_int:  0.920774454
p_ni:  0.0792255
p_wrong:  4.7e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.916592102
p_ni:  0.003425254
p_wrong:  0.079982644
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.913871124
p_ni:  0.002795858
p_wrong:  0.083333018
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: humancyc
NAD salvage pathway II
PathwayCommons: humancyc
NAD phosphorylation and dephosphorylation
Name
Explore in Pharos
Explore in Source
NAD salvage pathway II
NAD phosphorylation and dephosphorylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
15
8
17
7.4
99.4
BMI-adjusted hip circumference
3
11
17
98.7
hair color
2
2
0
1.1
93.5
BMI-adjusted waist circumference
7
12
24
92.5
lymphocyte count
3
2
3
91.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
17
7.4
99.4
BMI-adjusted hip circumference
17
98.7
hair color
0
1.1
93.5
BMI-adjusted waist circumference
24
92.5
lymphocyte count
3
91.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2-phosphoxylose phosphatase 1
VGNC:2528
470946
Macaque
2-phosphoxylose phosphatase 1
715229
Mouse
MGI:2442444
235534
Rat
RGD:1359617
315939
Dog
2-phosphoxylose phosphatase 1
VGNC:52898
611289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2-phosphoxylose phosphatase 1
Macaque
2-phosphoxylose phosphatase 1
Mouse
Rat
Dog
2-phosphoxylose phosphatase 1
Publication Statistics
PubMed Score 224.87
PubMed score by year
PubTator Score 5.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title