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Tbio
PXK
PX domain-containing protein kinase-like protein

Protein Summary
Description
Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356151
  • ENSP00000348472
  • ENSG00000168297
  • ENST00000383716
  • ENSP00000373222
  • ENST00000484288
  • ENSP00000417915

Symbol
  • SLOB
  • MONAKA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
virus perturbation
0.94
kinase perturbation
0.76
disease perturbation
0.74
phenotype
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.4   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.4   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
CCKBR
Tclin
Family:  GPCR
Novelty:  0.00158159
p_int:  0.996341771
p_ni:  0.003658226
p_wrong:  3e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
TMC6
Tbio
Family:  IC
Novelty:  0.00761789
p_int:  0.993459782
p_ni:  0.006540218
Score:  0.379
Data Source:  BioPlex,STRINGDB
USP48
Tbio
Family:  Enzyme
Novelty:  0.10103618
p_int:  0.987650487
p_ni:  0.012349513
Score:  0.262
Data Source:  BioPlex,STRINGDB
CLEC14A
Tbio
Novelty:  0.03231666
p_int:  0.985016875
p_ni:  0.014983125
Score:  0.345
Data Source:  BioPlex,STRINGDB
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.970160844
p_ni:  0.029835043
p_wrong:  0.000004112
Score:  0.169
Data Source:  BioPlex,STRINGDB
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
p_int:  0.790002364
p_ni:  0.209997634
p_wrong:  3e-9
Score:  0.182
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
Score:  0.764
Data Source:  STRINGDB
PHRF1
Tbio
Family:  Epigenetic
Novelty:  0.05250013
Score:  0.711
Data Source:  STRINGDB
BANK1
Tbio
Novelty:  0.02712029
Score:  0.673
Data Source:  STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
3
92.6
hemoglobin measurement
3
3
3
89.1
low density lipoprotein cholesterol measurement
4
5
5
88.2
aspartate aminotransferase measurement
2
2
1
13.3
85.7
platelet count
2
2
2
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
92.6
hemoglobin measurement
3
89.1
low density lipoprotein cholesterol measurement
5
88.2
aspartate aminotransferase measurement
1
13.3
85.7
platelet count
2
82.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PX domain containing serine/threonine kinase like
VGNC:7118
747514
Macaque
PX domain containing serine/threonine kinase like
706573
Mouse
MGI:1289230
218699
Rat
RGD:727819
306203
Dog
PX domain containing serine/threonine kinase like
VGNC:45219
476575
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PX domain containing serine/threonine kinase like
Macaque
PX domain containing serine/threonine kinase like
Mouse
Rat
Dog
PX domain containing serine/threonine kinase like
Publication Statistics
PubMed Score 42.40
PubMed score by year
PubTator Score 8.87
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title