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Tbio
PXDNL
Peroxidasin-like protein

Protein Summary
Description
Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356297
  • ENSP00000348645
  • ENSG00000147485

Symbol
  • VPO2
  • PMR1
  • PRM1
  • VPO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
phenotype
0.69
molecular function
0.63
tissue
0.61
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.49   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.49   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (13)
OSTF1
Tbio
Novelty:  0.000588
p_int:  0.892715123
p_ni:  0.107223304
p_wrong:  0.000061573
Score:  0.252
Data Source:  BioPlex,STRINGDB
PPP1R16B
Tbio
Family:  Enzyme
Novelty:  0.08773047
p_int:  0.869862058
p_ni:  0.13009954
p_wrong:  0.000038401
Score:  0.282
Data Source:  BioPlex,STRINGDB
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
Score:  0.535
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.471
Data Source:  STRINGDB
ODAM
Tbio
Novelty:  0.01922413
Score:  0.447
Data Source:  STRINGDB
PISD
Tbio
Family:  Enzyme
Novelty:  0.00966227
Score:  0.434
Data Source:  STRINGDB
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
Score:  0.434
Data Source:  STRINGDB
INSM2
Tbio
Family:  TF
Novelty:  0.01167787
Score:  0.431
Data Source:  STRINGDB
CACNA1B
Tclin
Family:  IC
Novelty:  0.00319692
Score:  0.422
Data Source:  STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.422
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
61.8
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxidasin like
VGNC:810
464171
Dog
peroxidasin like
VGNC:45218
486944
Opossum
peroxidasin like
100030443
C. elegans
181288
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxidasin like
Dog
peroxidasin like
Opossum
peroxidasin like
C. elegans
Publication Statistics
PubMed Score 13.49
PubMed score by year
PubTator Score 9.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title