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Tdark
PWWP2A
PWWP domain-containing protein 2A

Protein Summary
Description
H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307063
  • ENSP00000305151
  • ENSG00000170234
  • ENST00000456329
  • ENSP00000390462
  • ENST00000523662
  • ENSP00000428143

Symbol
  • KIAA1935
  • MST101
  • MST101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor binding site profile
0.68
tissue
0.65
virus perturbation
0.64
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999994612
p_ni:  0.000005353
p_wrong:  3.5e-8
Score:  0.283
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999992404
p_ni:  0.000007562
p_wrong:  3.4e-8
Data Source:  BioPlex
PHF14
Tbio
Family:  Epigenetic
Novelty:  0.13279118
Score:  0.786
Data Source:  STRINGDB
USP39
Tbio
Novelty:  0.03914006
Score:  0.647
Data Source:  STRINGDB
C16orf87
Tdark
Novelty:  5.71664261
Score:  0.605
Data Source:  STRINGDB
PHF6
Tbio
Family:  Epigenetic
Novelty:  0.00958984
Score:  0.547
Data Source:  STRINGDB
CEP89
Tbio
Novelty:  0.17461805
Score:  0.532
Data Source:  STRINGDB
SINHCAF
Tdark
Novelty:  0.18692832
Score:  0.517
Data Source:  STRINGDB
GCSAML
Tdark
Novelty:  0.65947854
Score:  0.51
Data Source:  STRINGDB
GOLGA5
Tbio
Novelty:  0.04940885
Score:  0.502
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
7
7
90.8
mean platelet volume
3
4
4
89.2
platelet crit
2
2
2
67.6
hematocrit
3
2
3
59.1
hemoglobin measurement
3
2
3
50.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
7
90.8
mean platelet volume
4
89.2
platelet crit
2
67.6
hematocrit
3
59.1
hemoglobin measurement
3
50.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PWWP domain containing 2A
VGNC:4140
471724
Macaque
PWWP domain containing 2A
696815
Mouse
MGI:1918052
70802
Rat
RGD:1305891
303060
Cow
PWWP domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29406]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PWWP domain containing 2A
Macaque
PWWP domain containing 2A
Mouse
Rat
Cow
PWWP domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29406]
Publication Statistics
PubMed Score 6.14
PubMed score by year
PubTator Score 1.87
PubTator score by year
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Related Publications
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PMID
Year
Title